| Autor: |
Martucci N; Department of Pathology, University of Pittsburgh School of MedicinePittsburgh, PAUSA., Michalopoulos GK; Department of Pathology, University of Pittsburgh School of MedicinePittsburgh, PAUSA., Mars WM; Department of Pathology, University of Pittsburgh School of MedicinePittsburgh, PAUSA. |
| Jazyk: |
angličtina |
| Zdroj: |
Gene expression [Gene Expr] 2021 Jun 11; Vol. 20 (3), pp. 201-207. Date of Electronic Publication: 2021 Jan 22. |
| DOI: |
10.3727/105221621X16113475275710 |
| Abstrakt: |
Integrin linked kinase (ILK) is a vital signaling protein ubiquitously expressed throughout the body. It binds to intracellular integrins to help promote signaling related to cell adhesion, apoptosis, proliferation, migration, and a plethora of other common cellular functions. In this review, ILKs role in the liver is detailed. Studies have shown ILK to be a major participant in hepatic ECM organization, liver regeneration, insulin resistance, and hepatocellular carcinoma. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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