Translational Regulation of Cancer Metastasis.

Autor:	Micalizzi DS; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Ebright RY; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Haber DA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts. maheswaran@helix.mgh.harvard.edu DHABER@mgh.harvard.edu.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Howard Hughes Medical Institute, Chevy Chase, Maryland., Maheswaran S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts. maheswaran@helix.mgh.harvard.edu DHABER@mgh.harvard.edu.; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.
Jazyk:	angličtina
Zdroj:	Cancer research [Cancer Res] 2021 Feb 01; Vol. 81 (3), pp. 517-524. Date of Electronic Publication: 2021 Jan 21.
DOI:	10.1158/0008-5472.CAN-20-2720
Abstrakt:	Deregulation of the mRNA translational process has been observed during tumorigenesis. However, recent findings have shown that deregulation of translation also contributes specifically to cancer cell spread. During metastasis, cancer cells undergo changes in cellular state, permitting the acquisition of features necessary for cell survival, dissemination, and outgrowth. In addition, metastatic cells respond to external cues, allowing for their persistence under significant cellular and microenvironmental stresses. Recent work has revealed the importance of mRNA translation to these dynamic changes, including regulation of cell states through epithelial-to-mesenchymal transition and tumor dormancy and as a response to external stresses such as hypoxia and immune surveillance. In this review, we focus on examples of altered translation underlying these phenotypic changes and responses to external cues and explore how they contribute to metastatic progression. We also highlight the therapeutic opportunities presented by aberrant mRNA translation, suggesting novel ways to target metastatic tumor cells. (©2021 American Association for Cancer Research.)
Databáze:	MEDLINE
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