Autor: |
Cuñarro-López Y; Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.; Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, Madrid 28009, Spain.; Health Research Institute Gregorio Marañón, 28009 Madrid, Spain., Pintado-Recarte P; Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.; Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, Madrid 28009, Spain.; Health Research Institute Gregorio Marañón, 28009 Madrid, Spain., Cueto-Hernández I; Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.; Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, Madrid 28009, Spain.; Health Research Institute Gregorio Marañón, 28009 Madrid, Spain., Hernández-Martín C; Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.; Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, Madrid 28009, Spain.; Health Research Institute Gregorio Marañón, 28009 Madrid, Spain., Payá-Martínez MP; Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.; Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, Madrid 28009, Spain.; Health Research Institute Gregorio Marañón, 28009 Madrid, Spain., Muñóz-Chápuli MDM; Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.; Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, Madrid 28009, Spain.; Health Research Institute Gregorio Marañón, 28009 Madrid, Spain., Cano-Valderrama Ó; Faculty of Medicine, Complutense University of Madrid, 28009 Madrid, Spain., Bravo C; Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Madrid, Spain.; Service of Gynecology and Obstetrics, Central University Hospital of Defense-UAH, Madrid 28047, Spain., Bujan J; Unit of Histology and Pathology, Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, Spain.; Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.; University Center for the Defense of Madrid (CUD-ACD), 28047 Madrid, Spain., Álvarez-Mon M; Unit of Histology and Pathology, Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, Spain.; Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.; University Center for the Defense of Madrid (CUD-ACD), 28047 Madrid, Spain.; Immune System Diseases-Rheumatology, Oncology Service an Internal Medicine, University Hospital Príncipe de Asturias, (CIBEREHD), 28806 Madrid, Spain., Ortega MA; Unit of Histology and Pathology, Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, Spain.; Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.; University Center for the Defense of Madrid (CUD-ACD), 28047 Madrid, Spain.; Cancer Registry and Pathology Department, Hospital Universitario Principe de Asturias, 28806 Madrid, Spain., De León-Luis JA; Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.; Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, Madrid 28009, Spain.; Health Research Institute Gregorio Marañón, 28009 Madrid, Spain. |
Abstrakt: |
SARS-CoV-2 is the novel member of coronavirus responsible for the worldwide pandemic COVID-19, affecting all types of people. In this context, established research identified pregnant women as a susceptible group of SARS-CoV-2 infection, although there is still limited data regarding the real impact of COVID-19 in this group. With that purpose, we conducted a systematic review describing the maternal-fetal results of pregnant women infected by SARS-CoV-2, in aim to analyze the profile of the obstetric patients according to the country of origin of the publication. A total of 38 articles were included in this systematic review with 2670 patients from 7 countries, with 20 works published from China (52.6%). We reported significative differences according to the median maternal age, with Spain as the country with the highest age (34.6 years); The percentage of tabaquism; proportion of symptomatic patients in the triage; type of radiological exam (China and France conduct CT scans on all their patients in comparison to the use of chest X-Ray in the rest of the countries studied); percentages of C-sections (83.9% in China; 35.9% Spain, p < 0.001); maternal mortality rate, proportion of patients who need treatments, the use of antivirals, antibiotics, and anticoagulants as well as measurements of the newborns. Perinatal results are favorable in the majority of countries, with very low rates of vertical transmission in the majority of works. The studies collected in this review showed moderate to high index of quality. The different works describe the affectation during the first wave of the pandemic, where the pregnant woman with SARS-CoV-2 infection is generally symptomatic during the third trimester of gestation along with other factors associated with worse prognosis of the disease, such as higher age, body mass index, and further comorbidities developed during pregnancy. In the obstetric patient, proportion of C-sections are elevated together with prematurity, increasing maternal perinatal morbimortality. Differences found between countries could be based on the proper profile of the patient in each region, the period of the pandemic directly affecting how it was managed, and the variations regarding in situ medical attention. |