Restructuring of amygdala subregion apportion across adolescence.

Autor:	Campbell CE; Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USA; Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, 90089-2520, USA., Mezher AF; Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USA; Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, 90089-2520, USA., Eckel SP; Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USA., Tyszka JM; Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, 91125, USA., Pauli WM; Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, 91125, USA., Nagel BJ; Departments of Psychiatry & Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, 97239-3098, USA., Herting MM; Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USA. Electronic address: herting@usc.edu.
Jazyk:	angličtina
Zdroj:	Developmental cognitive neuroscience [Dev Cogn Neurosci] 2021 Apr; Vol. 48, pp. 100883. Date of Electronic Publication: 2020 Dec 11.
DOI:	10.1016/j.dcn.2020.100883
Abstrakt:	Total amygdala volumes develop in association with sex and puberty, and postmortem studies find neuronal numbers increase in a nuclei specific fashion across development. Thus, amygdala subregions and composition may evolve with age. Our goal was to examine if amygdala subregion absolute volumes and/or relative proportion varies as a function of age, sex, or puberty in a large sample of typically developing adolescents (N = 408, 43 % female, 10-17 years). Utilizing the in vivo CIT168 atlas, we quantified 9 subregions and implemented Generalized Additive Mixed Models to capture potential non-linear associations with age and pubertal status between sexes. Only males showed significant age associations with the basolateral ventral and paralaminar subdivision (BLVPL), central nucleus (CEN), and amygdala transition area (ATA). Again, only males showed relative differences in the proportion of the BLVPL, CEN, ATA, along with lateral (LA) and amygdalostriatal transition area (ASTA), with age. Using a best-fit modeling approach, age, and not puberty, was found to drive these associations. The results suggest that amygdala subregions show unique variations with age in males across adolescence. Future research is warranted to determine if our findings may contribute to sex differences in mental health that emerge across adolescence. (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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