Restarting the Healing Process of Chronic Wounds Using a Novel Desiccant: A Prospective Case Series.
| Autor: | Cogo A; Villa Berica Hospital, Vicenza, Italy., Quint BJ; Penta Scientific BV, Amsterdam, The Netherlands., Bignozzi CA; Department of Chemical and Pharmaceutical Science, University of Ferrara, Ferrara, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | Wounds : a compendium of clinical research and practice [Wounds] 2021 Jan; Vol. 33 (1), pp. 1-8. |
| Abstrakt: | Introduction: Chronic skin wounds represent a major global health problem and financial burden. The blocked healing process of chronic wounds involves excess inflammatory proteins, persistent microbial burden, and often, drug-resistant biofilm on the wound bed. Wound-bed debridement is considered crucial to restart the healing process. Objective: The authors developed a novel desiccant (desiccating agent A) to serve as a new form of chemical debridement. The objective is to establish the working mechanism of desiccating agent A. Materials and Methods: Desiccating agent A was exposed to 7 pathogens in vitro and a prospective trial investigation was performed in vivo on 10 cases to establish a timeline to reach granulation. Results: The growth of a pool of the 7 pathogens showed an inhibition ring at 24 hours was 54 mm ± 5 mm. The prospective trial investigating 10 cases (5 females, 5 males) had a median age of 72.5 years (range, 50-90 years). The duration of the ulcers ranged from 6 weeks to 52 weeks (interquartile range, 6-24 weeks). The wound bed (median area, 64 cm2) was rinsed and dried. Desiccating agent A was applied directly to the wound bed with a gloved finger; after 30 to 60 seconds, desiccating agent A was rinsed and the remaining desiccated material was mechanically removed with dry sterile gauze. The wound bed was dried and covered with sterile gauze soaked in fitostimoline; dressings were changed as needed. The only observed side effect, transient pain, graded on a visual analog scale. Pain intensity ranged from 1 to 7 on a scale from 0 to 10. No nodules, welts, or blisters were observed. Median time to full granulation was 20.5 days (range, 7-78 days). Conclusions: These data support continued development of desiccating agent A as a chemical debridement agent. |
| Databáze: | MEDLINE |
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