| Autor: |
Campez M; Center for Children and Families, Florida International University., Raiker JS; Center for Children and Families, Florida International University., Little K; Marcus Autism Center., Altszuler AR; Center for Children and Families, Florida International University., Merrill BM; Center for Children and Families, Florida International University., Macphee FL; Center for Children and Families, Florida International University., Gnagy EM; Center for Children and Families, Florida International University., Greiner AR; Center for Children and Families, Florida International University., Musser ED; Center for Children and Families, Florida International University., Coles EK; Center for Children and Families, Florida International University., Pelham WE; Center for Children and Families, Florida International University. |
| Jazyk: |
angličtina |
| Zdroj: |
Experimental and clinical psychopharmacology [Exp Clin Psychopharmacol] 2022 Apr; Vol. 30 (2), pp. 209-219. Date of Electronic Publication: 2021 Jan 21. |
| DOI: |
10.1037/pha0000446 |
| Abstrakt: |
Individuals with Attention-Deficit Hyperactivity Disorder (ADHD) consistently exhibit a stronger preference for immediate rewards than for larger rewards available following a delay on tasks measuring choice impulsivity (CI). Despite this, however, there remains a dearth of studies examining the impact of stimulant treatment on CI as well as associated higher order (e.g., working memory [WM]) and perceptual (e.g., time perception) cognitive processes. The present study examines the effect of osmotic release oral system methylphenidate (OROS-MPH) on CI, WM and time perception processes as well as the relation among these processes before and after taking a regimen of OROS-MPH. Thirty-five children (aged 7-12 years) with a diagnosis of ADHD participating in a concurrent stimulant medication study were recruited to complete computerized assessments of CI, WM, and time perception. Children completed the assessments after administration of a placebo as well as their lowest effective dose of OROS-MPH following a 2-week titration period. The results from one-sample t-tests indicated that OROS-MPH improves both CI and WM in youth with ADHD but does not impact time perception. Further, results revealed no significant association among the various indices of cognitive performance while taking placebo or OROS-MPH. Overall, the findings suggest that while OROS-MPH improves both CI and WM in youth with ADHD, improvements in CI as a result of OROS-MPH are unlikely to be associated with the improvements in WM given the lack of association among the two. Future studies should consider alternate cognitive, emotional, and motivational mechanisms that may account for the impact of OROS-MPH on CI. (PsycInfo Database Record (c) 2022 APA, all rights reserved). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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