Efficacy of essential oil of cinnamon for the treatment of oral candidiasis: A randomized trial.

Autor: de Araújo MRC; Departament of Clinical and Social Dentistry, Federal University of Paraíba, João Pessoa, Brazil., Maciel PP; Departament of Clinical and Social Dentistry, Federal University of Paraíba, João Pessoa, Brazil., Castellano LRC; Technical Health School, Federal University of Paraíba, João Pessoa, Brazil., Bonan PRF; Departament of Clinical and Social Dentistry, Federal University of Paraíba, João Pessoa, Brazil., Alves DDN; Departament of Clinical and Social Dentistry, Federal University of Paraíba, João Pessoa, Brazil., de Medeiros ACD; Departament of Pharmaceutical Sciences, State University of Paraíba, Campina Grande, Brazil., de Castro RD; Departament of Clinical and Social Dentistry, Federal University of Paraíba, João Pessoa, Brazil.
Jazyk: angličtina
Zdroj: Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry [Spec Care Dentist] 2021 May; Vol. 41 (3), pp. 349-357. Date of Electronic Publication: 2021 Jan 21.
DOI: 10.1111/scd.12570
Abstrakt: Aim: It was analyzed the efficacy of mouthwash and spray containing essential oil (EO) of Cinnamomum zeylanicum Blume for the treatment of oral candidiasis.
Methods and Results: A randomized, controlled, and blinded clinical trial was conducted with 36 individuals (probabilistic sample) with oral candidiasis who were divided into two treatment groups: C. zeylanicum (0.5 mg/mL), n = 18; nystatin (100,000IU/mL), n = 18. The efficacy of the products was evaluated by two parameters: (a) clinical evolution recorded by calibrated examiners (Kappa = 0.822) according to Newton's classification and (b) reduction of colony-forming units/mL. Mycological and clinical parameters were analyzed before and at 15 days after treatment. Clinical examination of the mucosa showed that C. zeylanicum (p < 0.0339) and nystatin (p < .0139) had efficacy, resulting in a reduction of signs and symptoms (Mann-Whitney test). Mycological analysis showed that C. zeylanicum caused a reduction of 61% and 33% of Candida spp., isolates oral mucosa and dentures, respectively. Candida tropicalis strains were eliminated after C. zeylanicum, in both sites. The participants reported a pleasant taste and few product-related complaints.
Conclusion: C. zeylanicum EO and nystatin exhibited clinical efficacy, according to the Newton classification, and reducing in Candida spp. The clinical trial has been registered (Registration number: NBR-33s6 × 5, ensaiosclinicos.gov.br).
(© 2021 Special Care Dentistry Association and Wiley Periodicals LLC.)
Databáze: MEDLINE
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