Shorter telomeres in children with severe asthma, an indicative of accelerated aging.

Autor: Barbé-Tuana FM; Group of Inflammation and Cellular Senescence, Laboratory of Immunobiology, School of Health, Sciences and Life, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.; Postgraduate Program in Cellular and Molecular Biology, School of Health, Sciences and Life, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil., Grun LK; Group of Inflammation and Cellular Senescence, Laboratory of Immunobiology, School of Health, Sciences and Life, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.; Postgraduate Program in Pediatrics and Child Health, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.; Laboratory of Respiratory Physiology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil., Pierdoná V; Group of Inflammation and Cellular Senescence, Laboratory of Immunobiology, School of Health, Sciences and Life, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.; Postgraduate Program in Biological Sciences, Biochemistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil., Parisi MM; Group of Comprehensive Health Care, Centre for Health and Rural Sciences, University of Cruz Alta, Cruz Alta, Brazil., Friedrich F; Postgraduate Program in Pediatrics and Child Health, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.; Laboratory of Respiratory Physiology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil., Guma FTCR; Postgraduate Program in Biological Sciences, Biochemistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil., Pinto LA; Postgraduate Program in Pediatrics and Child Health, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.; Laboratory of Respiratory Physiology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil., Stein RT; Postgraduate Program in Pediatrics and Child Health, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.; Laboratory of Respiratory Physiology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil., Pitrez PMC; Pediatric Pulmonology Division, Hospital Moinhos de Vento, Porto Alegre, Brazil., Jones MH; Postgraduate Program in Pediatrics and Child Health, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.; Laboratory of Respiratory Physiology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
Jazyk: angličtina
Zdroj: Aging [Aging (Albany NY)] 2021 Jan 20; Vol. 13 (2), pp. 1686-1691. Date of Electronic Publication: 2021 Jan 20.
DOI: 10.18632/aging.202527
Abstrakt: Severe therapy-resistant asthma (STRA) is closely associated with distinct clinical and inflammatory pheno-endotypes, which may contribute to the development of age-related comorbidities. Evidence has demonstrated a contribution of accelerated telomere shortening on the poor prognosis of respiratory diseases in adults. Eotaxin-1 (CCL11) is an important chemokine for eosinophilic recruitment and the progression of asthma. In the last years has also been proposed as an age-promoting factor. This study aimed to investigate the association of relative telomere length (rTL) and eotaxin-1 in asthmatic children. Children aged 8-14 years (n=267) were classified as healthy control (HC, n=126), mild asthma (MA, n=124) or severe therapy-resistant asthma (STRA, n=17). rTL was performed by qPCR from peripheral blood. Eotaxin-1 was quantified by ELISA from fresh-frozen plasma. STRA had shorter telomeres compared to HC ( p =0.02) and MA ( p =0.006). Eotaxin-1 levels were up-regulated in STRA [median; IQR25-75)] [(1,190 pg/mL; 108-2,510)] compared to MA [(638 pg/mL; 134-1,460)] ( p =0.03) or HC [(627 pg/mL; 108-1,750)] ( p <0.01). Additionally, shorter telomeres were inversely correlated with eotaxin-1 levels in STRA (r=-0.6, p =0.013). Our results suggest that short telomeres and up-regulated eotaxin-1, features of accelerated aging, could prematurely contribute to a senescent phenotype increasing the risk for early development of age-related diseases in asthma.
Databáze: MEDLINE