Placenta Pathology From Term Born Neonates With Normal or Adverse Outcome.

Autor:	Nikkels PG; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands., Evers AC; Department of Obstetrics, University Medical Center Utrecht, Utrecht, the Netherlands., Schuit E; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands., Brouwers HA; Department of Neonatology, University Medical Center Utrecht, Utrecht, the Netherlands., Bruinse HW; Department of Obstetrics, University Medical Center Utrecht, Utrecht, the Netherlands., Bont L; Department of Pediatrics, Utrecht University Medical Center Utrecht, Utrecht, the Netherlands., Houben ML; Department of Pediatrics, Utrecht University Medical Center Utrecht, Utrecht, the Netherlands., Kwee A; Department of Obstetrics, University Medical Center Utrecht, Utrecht, the Netherlands.
Jazyk:	angličtina
Zdroj:	Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society [Pediatr Dev Pathol] 2021 Mar-Apr; Vol. 24 (2), pp. 121-130. Date of Electronic Publication: 2021 Jan 20.
DOI:	10.1177/1093526620980608
Abstrakt:	Background: The incidence of umbilical cord or placental parenchyma abnormalities associated with mortality or morbidity of term infants is lacking. Methods: Placentas of 55 antepartum stillbirths (APD), 21 intrapartum stillbirths (IPD), 12 neonatal deaths (ND), and 80 admissions to a level 3 neonatal intensive care unit (NS) were studied and compared with 439 placentas from neonates from normal term pregnancies and normal outcome after vaginal delivery (NPVD) and with 105 placentas after an elective caesarian sections (NPEC). Results: NPVD and NPEC placentas showed no or one abnormality in 70% and placentas from stillbirth showed two or more abnormalities in 80% of cases. APD placentas more frequently had a low weight and less formation of terminal villi. Hypercoiling was more often present in all study groups. Severe chronic villitis was almost exclusively present in APD placentas. Chorioamnionitis was significantly more frequent in APD, IPD and NS placentas and funisitis was more often observed in IPD and NS placentas. Conclusion: Multiple placental abnormalities are significantly more frequent in placentas from term neonates with severe perinatal morbidity and mortality. These placental abnormalities are thought to be associated with disturbed oxygen transfer or with inflammation.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu