Effect of antimicrobials on Stenotrophomonas maltophilia biofilm.

Autor:	Santos Carvalhais BE; Department of Pathology, Health Sciences Center, Federal University of Espírito Santo (UFES), Av. Marechal Campos, Vitória, Espírito Santo 1468 29040 090, Brazil., Souza E Silva C; Department of Pathology, Health Sciences Center, Federal University of Espírito Santo (UFES), Av. Marechal Campos, Vitória, Espírito Santo 1468 29040 090, Brazil., Dos Santos KV; Department of Pathology, Health Sciences Center, Federal University of Espírito Santo (UFES), Av. Marechal Campos, Vitória, Espírito Santo 1468 29040 090, Brazil.
Jazyk:	angličtina
Zdroj:	Future microbiology [Future Microbiol] 2021 Jan; Vol. 16 (2), pp. 83-93. Date of Electronic Publication: 2021 Jan 20.
DOI:	10.2217/fmb-2020-0115
Abstrakt:	Aim: To evaluate the activity of five antimicrobials against young and mature Stenotrophomonas maltophilia biofilms. Materials & methods: Nineteen clinical strains from hemoculture of hemodialysis patients were tested for biofilm kinetics, MIC and minimum biofilm inhibitory concentration (MBIC) in young and mature biofilms. Results: All strains were moderate biofilm producers. MIC showed total susceptibility to levofloxacin and trimethoprim-sulfamethoxazole and partial resistance to ceftazidime (63.2%) and gentamicin (21%). Young and mature biofilms showed the lowest MBIC/MIC ratio for gentamicin, chloramphenicol and levofloxacin, respectively. The highest MBIC/MIC was for trimethoprim-sulfamethoxazole (young) and ceftazidime (mature). Conclusion: Gentamicin displayed surprising activity against S. maltophilia biofilms. Chloramphenicol was indicated as a good option against young S. maltophilia biofilms, and trimethoprim-sulfamethoxazole showed limited antibiofilm activity.
Databáze:	MEDLINE
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