Optical coherence tomography angiography findings in patients with Alport syndrome.

Autor:	Trancoso FG; Department of Ophthalmology, Hospital Evangélico de Vila Velha, Vila Velha, ES, Brazil., Gallon L; Department of Ophthalmology, Hospital Evangélico de Vila Velha, Vila Velha, ES, Brazil., Bomfim MLA; Department of Ophthalmology, Hospital Evangélico de Vila Velha, Vila Velha, ES, Brazil., Silva AFMD; Department of Ophthalmology, Hospital Evangélico de Vila Velha, Vila Velha, ES, Brazil., Cade F; Department of Ophthalmology, Hospital Evangélico de Vila Velha, Vila Velha, ES, Brazil., Zanetti FR; Department of Ophthalmology, Hospital Evangélico de Vila Velha, Vila Velha, ES, Brazil.
Jazyk:	angličtina
Zdroj:	Arquivos brasileiros de oftalmologia [Arq Bras Oftalmol] 2020 Nov-Dec; Vol. 83 (6), pp. 473-477.
DOI:	10.5935/0004-2749.20200088
Abstrakt:	Purpose: To describe the findings on optical coherence tomography angiography associated with Alport syndrome. Methods: Descriptive study from a referral ophthalmology service (Hospital Evangélico de Vila Velha, Brazil). Patients diagnosed with Alport syndrome were included. Results: The study group consisted of four patients (one female and three males) diagnosed with Alport syndrome. Visual acuity in the worst eye was between 20/40 and 20/60. All male patients had anterior lenticonus on biomicroscopy. The observed retinal findings included dots and flecks and pigmentary changes in the macula. On optical coherence tomography angiography, the inner retinal layers of all patients displayed thinning (especially in the temporal quadrant of the macula) and an increase in the foveal avascular zone. A thick choroid was observed in both eyes of the two youngest patients. Conclusions: In patients with Alport syndrome, the inner retinal layers suffer changes due to type IV collagen mutations. Optical coherence tomography angiography makes it possible to visualize and document these findings, making it a useful tool in the detection of early retinal findings associated with Alport syndrome.
Databáze:	MEDLINE
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