Differential effect of vascularity between long- and short-term survivors with IDH1/2 wild-type glioblastoma.

Autor: Álvarez-Torres MDM; ITACA, Universitat Politècnica de València, Valencia, Spain., Fuster-García E; Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway., Reynés G; Cancer Research Group, Health Research Institute Hospital La Fe, Valencia, Spain., Juan-Albarracín J; ITACA, Universitat Politècnica de València, Valencia, Spain., Chelebian E; ITACA, Universitat Politècnica de València, Valencia, Spain., Oleaga L; Hospital Clinic de Barcelona, Barcelona, Spain., Pineda J; Hospital Clinic de Barcelona, Barcelona, Spain., Auger C; Magnetic Resonance Unit, Department of Radiology, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain., Rovira A; Magnetic Resonance Unit, Department of Radiology, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain., Emblem KE; Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway., Filice S; Medical Physics, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy., Mollà-Olmos E; Departamento de Radiodiagnóstico, Hospital Universitario de la Ribera, Alzira, Spain., García-Gómez JM; ITACA, Universitat Politècnica de València, Valencia, Spain.
Jazyk: angličtina
Zdroj: NMR in biomedicine [NMR Biomed] 2021 Apr; Vol. 34 (4), pp. e4462. Date of Electronic Publication: 2021 Jan 19.
DOI: 10.1002/nbm.4462
Abstrakt: Introduction: IDH1/2 wt glioblastoma (GB) represents the most lethal tumour of the central nervous system. Tumour vascularity is associated with overall survival (OS), and the clinical relevance of vascular markers, such as rCBV, has already been validated. Nevertheless, molecular and clinical factors may have different influences on the beneficial effect of a favourable vascular signature.
Purpose: To evaluate the association between the rCBV and OS of IDH1/2 wt GB patients for long-term survivors (LTSs) and short-term survivors (STSs). Given that initial high rCBV may affect the patient's OS in follow-up stages, we will assess whether a moderate vascularity is beneficial for OS in both groups of patients.
Materials and Methods: Ninety-nine IDH1/2 wt GB patients were divided into LTSs (OS ≥ 400 days) and STSs (OS < 400 days). Mann-Whitney and Fisher, uni- and multiparametric Cox, Aalen's additive regression and Kaplan-Meier tests were carried out. Tumour vascularity was represented by the mean rCBV of the high angiogenic tumour (HAT) habitat computed through the haemodynamic tissue signature methodology (available on the ONCOhabitats platform).
Results: For LTSs, we found a significant association between a moderate value of rCBV mean and higher OS (uni- and multiparametric Cox and Aalen's regression) (p = 0.0140, HR = 1.19; p = 0.0085, HR = 1.22) and significant stratification capability (p = 0.0343). For the STS group, no association between rCBV mean and survival was observed. Moreover, no significant differences (p > 0.05) in gender, age, resection status, chemoradiation, or MGMT methylation were observed between LTSs and STSs.
Conclusion: We have found different prognostic and stratification effects of the vascular marker for the LTS and STS groups. We propose the use of rCBV mean at HAT as a vascular marker clinically relevant for LTSs with IDH1/2 wt GB and maybe as a potential target for randomized clinical trials focused on this group of patients.
(© 2021 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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