Detection of antibodies to duck tembusu virus in human population with or without the history of contact with ducks.

Autor: Pulmanausahakul R; Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand., Ketsuwan K; Institute of Molecular Biosciences, Mahidol University, Bangkok, Thailand., Jaimipuk T; Institute of Molecular Biosciences, Mahidol University, Bangkok, Thailand., Smith DR; Institute of Molecular Biosciences, Mahidol University, Bangkok, Thailand., Auewarakul P; Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand., Songserm T; Faculty of Veterrinary Medicine, Kasetsart University, Bangkok, Thailand.
Jazyk: angličtina
Zdroj: Transboundary and emerging diseases [Transbound Emerg Dis] 2022 Mar; Vol. 69 (2), pp. 870-873. Date of Electronic Publication: 2021 Feb 07.
DOI: 10.1111/tbed.13998
Abstrakt: Duck tembusu virus (DTMUV) is an emerging duck pathogen in China and other Asian countries. It is unclear whether this emerging zoonotic infection poses a threat to humans. A previous study in 2012 showed surprisingly high rates of seropositivity and positive viral detection by RT-PCR in duck farm workers in China. To understand the nature of the threat of this emerging virus, we studied the neutralizing antibody response to a local isolate of DTMUV in an at-risk population, who were workers in duck farms and residents around farming areas in Central Thailand where DTMUV had been previously detected, and in a not-at-risk population, who were people living in the same or neighbouring province, but at a distance from the farms and who had no contact with ducks. The sera from the at-risk population showed higher anti-DTMUV neutralizing antibody titres as compared with those of the not-at-risk population. However, within the at-risk population, workers with direct contact with ducks did not show higher neutralizing titres than those without direct contact. Interestingly, some people in the not-at-risk group also displayed high neutralizing antibody titres to DTMUV. These sera were tested against other endemic Flaviviruses and showed no or low cross-reactivity suggesting the specificity of the neutralizing activity against DTMUV. These data raise a possibility of DTMUV as a potential zoonotic pathogen but the mode of transmission of the virus from ducks or other possible hosts to humans should be explored further.
(© 2021 Wiley-VCH GmbH.)
Databáze: MEDLINE
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