Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women.

Autor: Cruz-Lemini M; Department of Gynecology and Obstetrics, Women and Perinatal Health Research Group, Biomedical Research Institute (IIB-Sant Pau), Santa Creu i Sant Pau University Hospital, 08025 Barcelona, Spain., Ferriols Perez E; Department of Gynecology and Obstetrics, Parc de Salut Mar University Hospital, 08003 Barcelona, Spain., de la Cruz Conty ML; Fundacion de Investigacion Biomedica, Puerta de Hierro University Hospital of Majadahonda, 28222 Madrid, Spain., Caño Aguilar A; Department of Gynecology and Obstetrics, San Cecilio University Hospital of Granada, 18016 Granada, Spain., Encinas Pardilla MB; Department of Gynecology and Obstetrics, Puerta de Hierro University Hospital of Majadahonda, 28222 Madrid, Spain., Prats Rodríguez P; Department of Gynecology and Obstetrics, Dexeus University Hospital, 08028 Barcelona, Spain., Muner Hernando M; Department of Gynecology and Obstetrics, La Paz University Hospital, 28046 Madrid, Spain., Forcen Acebal L; Department of Gynecology and Obstetrics, Doce de Octubre University Hospital, 28041 Madrid, Spain., Pintado Recarte P; Department of Gynecology and Obstetrics, Gregorio Marañon University Hospital, 28007 Madrid, Spain., Medina Mallen MDC; Department of Gynecology and Obstetrics, Women and Perinatal Health Research Group, Biomedical Research Institute (IIB-Sant Pau), Santa Creu i Sant Pau University Hospital, 08025 Barcelona, Spain., Perez Perez N; Department of Gynecology and Obstetrics, San Carlos University Hospital, 28040 Madrid, Spain., Canet Rodriguez J; Department of Gynecology and Obstetrics, Santa Caterina Hospital, 17190 Girona, Spain., Villalba Yarza A; Department of Gynecology and Obstetrics, University Hospital of Salamanca, 37007 Salamanca, Spain., Nieto Velasco O; Department of Gynecology and Obstetrics, Quironsalud Madrid University Hospital, 28223 Madrid, Spain., Del Barrio Fernandez PG; Department of Gynecology and Obstetrics, Getafe University Hospital, 28905 Madrid, Spain., Orizales Lago CM; Department of Gynecology and Obstetrics, Severo Ochoa University Hospital, 28911 Madrid, Spain., Marcos Puig B; Department of Gynecology and Obstetrics, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain., Muñoz Abellana B; Department of Gynecology and Obstetrics, Sant Joan de Reus University Hospital, 43204 Tarragona, Spain., Fuentes Ricoy L; Department of Gynecology and Obstetrics, University Hospital of Ferrol, 15405 A Coruña, Spain., Rodriguez Vicente A; Department of Gynecology and Obstetrics, Doctor Josep Trueta University Hospital of Girona, 17007 Girona, Spain., Janeiro Freire MJ; Department of Gynecology and Obstetrics, University Hospital Complex of A Coruña, 15006 A Coruña, Spain., Alferez Alvarez-Mallo M; Department of Gynecology and Obstetrics, HM Hospitals, 28015 Madrid, Spain., Casanova Pedraz C; Department of Gynecology and Obstetrics, University Hospital of Torrejon, 28850 Madrid, Spain., Alomar Mateu O; Department of Gynecology and Obstetrics, Regional Hospital of Inca, 07300 Illes Balears, Spain., Lesmes Heredia C; Department of Gynecology and Obstetrics, Parc Taulí Hospital, 08208 Barcelona, Spain., Wizner de Alva JC; Department of Gynecology and Obstetrics, San Pedro de Alcántara Hospital, 10003 Cáceres, Spain., Posadas San Juan A; Department of Gynecology and Obstetrics, Rio Hortega University Hospital, 47012 Valladolid, Spain., Macia Badia M; Department of Gynecology and Obstetrics, Arnau de Vilanova University Hospital, 25198 Lleida, Spain., Alvarez Colomo C; Department of Gynecology and Obstetrics, Valladolid University Clinical Hospital, 47003 Valladolid, Spain., Sanchez Muñoz A; Department of Gynecology and Obstetrics, General University Hospital of Ciudad Real, 13005 Ciudad Real, Spain., Pratcorona Alicart L; Department of Gynecology and Obstetrics, Germans Trias i Pujol University Hospital, 08916 Barcelona, Spain., Alonso Saiz R; Department of Gynecology and Obstetrics, University Hospital of Burgos, 09006 Burgos, Spain., Lopez Rodriguez M; Department of Gynecology and Obstetrics, Joan XXIII University Hospital of Tarragona, 43005 Tarragona, Spain., Barbancho Lopez MC; Department of Gynecology and Obstetrics, Infanta Sofia University Hospital, 28703 Madrid, Spain., Meca Casbas MR; Department of Gynecology and Obstetrics, Poniente Hospital of Almeria, 04700 Almeria, Spain., Vaquerizo Ruiz O; Department of Gynecology and Obstetrics, University Hospital of Cabueñes, 33394 Asturias, Spain., Moran Antolin E; Department of Gynecology and Obstetrics, Son Espases University Hospital, 07120 Illes Balears, Spain., Nuñez Valera MJ; Department of Gynecology and Obstetrics, Virgen de la Luz Hospital, 16002 Cuenca, Spain., Fernandez Fernandez C; Department of Gynecology and Obstetrics, University Assistance Complex of Leon, 24001 Leon, Spain., Tubau Navarra A; Department of Gynecology and Obstetrics, Son Llatzer University Hospital, 07198 Illes Balears, Spain., Cano Garcia AM; Department of Gynecology and Obstetrics, University Hospital of El Tajo, 28300 Madrid, Spain., Soldevilla Perez S; Department of Gynecology and Obstetrics, University Hospital of Jerez de la Frontera, 11407 Cadiz, Spain., Gattaca Abasolo I; Department of Gynecology and Obstetrics, Txagorritxu University Hospital of Araba, 01009 Araba, Spain., Adanez Garcia J; Department of Gynecology and Obstetrics, Central University Hospital of Asturias, 33011 Asturias, Spain., Puertas Prieto A; Department of Gynecology and Obstetrics, Virgen de las Nieves University Hospital, 18014 Granada, Spain., Ostos Serna R; Department of Gynecology and Obstetrics, Virgen de Valme University Hospital, 41014 Sevilla, Spain., Guadix Martin MDP; Department of Gynecology and Obstetrics, Virgen Macarena University Hospital, 41009 Sevilla, Spain., Catalina Coello M; Department of Gynecology and Obstetrics, Virgen de la Concha Hospital, 49022 Zamora, Spain., Espuelas Malon S; Department of Gynecology and Obstetrics, Parc de Salut Mar University Hospital, 08003 Barcelona, Spain., Sainz Bueno JA; Department of Gynecology and Obstetrics, G. Chacon (Viamed Santa Angela de la Cruz Hospital), 41014 Sevilla, Spain., Granell Escobar MR; Department of Gynecology and Obstetrics, Juan Ramon Jimenez University Hospital, 21005 Huelva, Spain., Cruz Melguizo S; Department of Gynecology and Obstetrics, Puerta de Hierro University Hospital of Majadahonda, 28222 Madrid, Spain., Martinez Perez O; Department of Gynecology and Obstetrics, Puerta de Hierro University Hospital of Majadahonda, 28222 Madrid, Spain., On Behalf Of The Spanish Obstetric Emergency Group
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2021 Jan 15; Vol. 13 (1). Date of Electronic Publication: 2021 Jan 15.
DOI: 10.3390/v13010112
Abstrakt: Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13-3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms.
Databáze: MEDLINE
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