Mechanisms and functions of calcium microdomains produced by ORAI channels, d-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors.

Autor: Guse AH; The Calcium Signalling Group, Dept of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany. Electronic address: guse@uke.de., Gil Montoya DC; The Calcium Signalling Group, Dept of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany., Diercks BP; The Calcium Signalling Group, Dept of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.
Jazyk: angličtina
Zdroj: Pharmacology & therapeutics [Pharmacol Ther] 2021 Jul; Vol. 223, pp. 107804. Date of Electronic Publication: 2021 Jan 16.
DOI: 10.1016/j.pharmthera.2021.107804
Abstrakt: With the discovery of local Ca 2+ signals in the 1990s the concept of 'elementary Ca 2+ signals' and 'fundamental Ca 2+ signals' was developed. While 'elementary Ca 2+ signals' relate to optical signals gained by activity of small clusters of Ca 2+ channels, 'fundamental signals' describe such optical signals that arise from opening of single Ca 2+ channels. In this review, we discuss (i) concepts of local Ca 2+ signals and Ca 2+ microdomains, (ii) molecular mechanisms underlying Ca 2+ microdomains, (iii) functions of Ca 2+ microdomains, and (iv) mathematical modelling of Ca 2+ microdomains. We focus on Ca 2+ microdomains produced by ORAI channels, D-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors. In summary, research on local Ca 2+ signals in different cell models aims to better understand how cells use the Ca 2+ toolkit to produce Ca 2+ microdomains as relevant signals for specific cellular responses, but also how local Ca 2+ signals as building blocks merge into global Ca 2+ signaling.
Competing Interests: Declaration of Competing Interest The authors declare that there are no conflicts of interest.
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
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