Excitatory-inhibitory balance within EEG microstates and resting-state fMRI networks: assessed via simultaneous trimodal PET-MR-EEG imaging.

Autor:	Rajkumar R; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany.; JARA-BRAIN, 52074, Aachen, Germany., Régio Brambilla C; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany.; JARA-BRAIN, 52074, Aachen, Germany., Veselinović T; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany., Bierbrier J; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.; Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada., Wyss C; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.; Department for Psychiatry, Psychotherapy and Psychosomatics Social Psychiatry, University Hospital of Psychiatry Zurich, Zurich, Switzerland., Ramkiran S; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany., Orth L; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany., Lang M; Institute of Neuroscience and Medicine 5, INM-5, Forschungszentrum Jülich, Jülich, Germany., Rota Kops E; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany., Mauler J; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany., Scheins J; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany., Neumaier B; Institute of Neuroscience and Medicine 5, INM-5, Forschungszentrum Jülich, Jülich, Germany., Ermert J; Institute of Neuroscience and Medicine 5, INM-5, Forschungszentrum Jülich, Jülich, Germany., Herzog H; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany., Langen KJ; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.; JARA-BRAIN, 52074, Aachen, Germany.; Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany., Binkofski FC; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.; JARA-BRAIN, 52074, Aachen, Germany.; Division of Clinical Cognitive Sciences, RWTH Aachen University, Aachen, Germany., Lerche C; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany., Shah NJ; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.; JARA-BRAIN, 52074, Aachen, Germany.; Division of Clinical Cognitive Sciences, RWTH Aachen University, Aachen, Germany.; Institute of Neuroscience and Medicine 11, INM-11, Forschungszentrum Jülich, Jülich, Germany., Neuner I; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany. i.neuner@fz-juelich.de.; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany. i.neuner@fz-juelich.de.; JARA-BRAIN, 52074, Aachen, Germany. i.neuner@fz-juelich.de.
Jazyk:	angličtina
Zdroj:	Translational psychiatry [Transl Psychiatry] 2021 Jan 18; Vol. 11 (1), pp. 60. Date of Electronic Publication: 2021 Jan 18.
DOI:	10.1038/s41398-020-01160-2
Abstrakt:	The symbiosis of neuronal activities and glucose energy metabolism is reflected in the generation of functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) signals. However, their association with the balance between neuronal excitation and inhibition (E/I-B), which is closely related to the activities of glutamate and γ-aminobutyric acid (GABA) and the receptor availability (RA) of GABA A and mGluR5, remains unexplored. This research investigates these associations during the resting state (RS) condition using simultaneously recorded PET/MR/EEG (trimodal) data. The trimodal data were acquired from three studies using different radio-tracers such as, [ 11 C]ABP688 (ABP) (N = 9), [ 11 C]Flumazenil (FMZ) (N = 10) and 2-[ 18 F]fluoro-2-deoxy-D-glucose (FDG) (N = 10) targeted to study the mGluR5, GABA A receptors and glucose metabolism respectively. Glucose metabolism and neuroreceptor binding availability (non-displaceable binding potential (BP ND )) of GABA A and mGluR5 were found to be significantly higher and closely linked within core resting-state networks (RSNs). The neuronal generators of EEG microstates and the fMRI measures were most tightly associated with the BP ND of GABA A relative to mGluR5 BP ND and the glucose metabolism, emphasising a predominance of inhibitory processes within in the core RSNs at rest. Changes in the neuroreceptors leading to an altered coupling with glucose metabolism may render the RSNs vulnerable to psychiatric conditions. The paradigm employed here will likely help identify the precise neurobiological mechanisms behind these alterations in fMRI functional connectivity and EEG oscillations, potentially benefitting individualised healthcare treatment measures.
Databáze:	MEDLINE
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