[Nephrocalcinosis in children].

Autor: Monet-Didailler C; Service de pédiatrie, unité de néphrologie pédiatrique, centre de références des maladies rénales rares, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France., Chateil JF; Service de radiologie et d'imagerie anténatale, de l'enfant et de la femme, CHU de Bordeaux, 33000 Bordeaux, France., Allard L; Service de pédiatrie, unité de néphrologie pédiatrique, centre de références des maladies rénales rares, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France., Godron-Dubrasquet A; Service de pédiatrie, unité de néphrologie pédiatrique, centre de références des maladies rénales rares, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France., Harambat J; Service de pédiatrie, unité de néphrologie pédiatrique, centre de références des maladies rénales rares, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France. Electronic address: jerome.harambat@chu-bordeaux.fr.
Jazyk: francouzština
Zdroj: Nephrologie & therapeutique [Nephrol Ther] 2021 Feb; Vol. 17 (1), pp. 58-66. Date of Electronic Publication: 2021 Jan 15.
DOI: 10.1016/j.nephro.2020.12.001
Abstrakt: Nephrocalcinosis is defined by calcium phosphate or calcium oxalate deposits in the kidney parenchyma, particularly in tubular epithelial cells and interstitial tissue. It should be differentiated from urolithiasis where calcium salts deposits are located in the kidney and urinary tract. The epidemiology of nephrocalcinosis in children is unknown but the condition is not so rare, with an increased incidence in preterm infants. Often detected as an incidental finding, nephrocalcinosis may be classified according to the radiological type: medullary, cortical or diffuse. Nephrocalcinosis in children can be caused by a variety of etiology. The most common causes concern medullary nephrocalcinosis and include hereditary tubular disorders, in particular distal renal tubular acidosis and Dent disease, metabolic disorders such as idiopathic hypercalciuria and hyperoxaluria, and iatrogenic causes such as vitamin D intoxication. In the newborn, the main cause is hypercalciuria of the premature baby, whose multifactorial origin is largely iatrogenic. Primary hyperoxaluria which can lead to early onset nephrocalcinosis and usually to chronic kidney disease should always be considered and further investigated. In order to provide a specific diagnosis, it is essential to take into account the family history, the clinical context and complete laboratory data. Early initiation of an appropriate etiological treatment is recommended and may prevent or delay the progression to chronic kidney disease in some cases.
(Copyright © 2020 Société francophone de néphrologie, dialyse et transplantation. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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