Rabeprazole: A comprehensive profile.
| Autor: | Bakheit AH; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia; Department of Chemistry, Faculty of Science and Technology, Al-Neelain University, Khartoum, Sudan. Electronic address: abujazz76@gmail.com., Al-Kahtani HM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia., Albraiki S; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia. |
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| Jazyk: | angličtina |
| Zdroj: | Profiles of drug substances, excipients, and related methodology [Profiles Drug Subst Excip Relat Methodol] 2021; Vol. 46, pp. 137-183. Date of Electronic Publication: 2020 Aug 13. |
| DOI: | 10.1016/bs.podrm.2020.07.003 |
| Abstrakt: | Rabeprazole belongs to the class of anti-secretory drugs, with benzimidazoles substitution. These drugs induce gastric acid secretion through precise inhibition of the enzyme H + /K + -ATPase (acid or proton pump). This effect helps to treat and prevent conditions in which gastric acid directly aggravates symptoms such as duodenal and gastric ulcers. This chapter includes a comprehensive review of rabeprazole in terms of nomenclature, its physical-chemical properties, methods of preparation and ADME profiles. In addition, the chapter also includes a review of several methods for analysis of rebeprazole in its dosage forms and biological fluids. (© 2021 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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