Exosomes from adipose-derived stem cells and application to skin wound healing.

Autor: An Y; Department of Plastic Surgery, Peking University Third Hospital, Beijing, China., Lin S; Hearing Ctr, Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China., Tan X; Department of Plastic Surgery, Peking University Third Hospital, Beijing, China., Zhu S; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China., Nie F; Department of Plastic Surgery, Peking University Third Hospital, Beijing, China., Zhen Y; Department of Plastic Surgery, Peking University Third Hospital, Beijing, China., Gu L; Department of Plastic Surgery, Peking University Third Hospital, Beijing, China., Zhang C; Institute of Systems Biomedicine, Peking University, Beijing, China., Wang B; Department of Plastic Surgery, Peking University Third Hospital, Beijing, China., Wei W; Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China., Li D; Department of Plastic Surgery, Peking University Third Hospital, Beijing, China., Wu J; Hearing Ctr, Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Jazyk: angličtina
Zdroj: Cell proliferation [Cell Prolif] 2021 Mar; Vol. 54 (3), pp. e12993. Date of Electronic Publication: 2021 Jan 17.
DOI: 10.1111/cpr.12993
Abstrakt: Skin wound healing is an intractable problem that represents an urgent clinical need. To solve this problem, a large number of studies have focused on the use of exosomes (EXOs) derived from adipose-derived stem cells (ADSCs). This review describes the mechanisms whereby ADSCs-EXOs regulate wound healing and their clinical application. In the wound, ADSCs-EXOs modulate immune responses and inflammation. They also promote angiogenesis, accelerate proliferation and re-epithelization of skin cells, and regulate collagen remodelling which inhibits scar hyperplasia. Compared with ADSCs therapeutics, ADSCs-EXOs have highly stability and are easily stored. Additionally, they are not rejected by the immune system and have a homing effect and their dosage can be easily controlled. ADSCs-EXOs can improve fat grafting and promote wound healing in patients with diabetes mellitus. They can also act as a carrier and combined scaffold for treatment, leading to scarless cutaneous repair. Overall, ADSCs-EXOs have the potential to be used in the clinic to promote wound healing.
(© 2021 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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