Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA).

Autor: Leidhin CN; School of Medicine, Trinity College Dublin, Ireland; The National Centre for Advanced Medical Imaging (CAMI), St. James's Hospital, Dublin, Ireland., McMorrow J; School of Medicine, Trinity College Dublin, Ireland; The National Centre for Advanced Medical Imaging (CAMI), St. James's Hospital, Dublin, Ireland., Carey D; School of Medicine, Trinity College Dublin, Ireland; The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Ireland., Newman L; School of Medicine, Trinity College Dublin, Ireland; The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Ireland., Williamson W; School of Medicine, Trinity College Dublin, Ireland; The Global Brain Health Institute (GBHI), Trinity College Dublin, Ireland., Fagan AJ; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Chappell MA; Radiological Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Sir Peter Mansfield Imaging Center, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Nottingham Biomedical Research Centre, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom; Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Kenny RA; School of Medicine, Trinity College Dublin, Ireland; The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Ireland; The Global Brain Health Institute (GBHI), Trinity College Dublin, Ireland; Mercer's Institute for Successful Ageing, St. James's Hospital, Dublin, Ireland., Meaney JF; School of Medicine, Trinity College Dublin, Ireland; The National Centre for Advanced Medical Imaging (CAMI), St. James's Hospital, Dublin, Ireland., Knight SP; School of Medicine, Trinity College Dublin, Ireland; The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Ireland. Electronic address: silvin.knight@tcd.ie.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2021 Apr 01; Vol. 229, pp. 117741. Date of Electronic Publication: 2021 Jan 14.
DOI: 10.1016/j.neuroimage.2021.117741
Abstrakt: Objective: To establish normative reference values for total grey matter cerebral blood flow (CBF GM ) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged 54 years and older.
Background: Quantitative assessment of CBF GM may provide an imaging biomarker for the early detection of those at risk of neurodegenerative diseases, such as Alzheimer's and dementia. However, the use of this method to differentiate normal age-related decline in CBF GM from pathological reduction has been hampered by the lack of reference values for cerebral perfusion.
Methods: The study cohort comprised a subset of wave 3 (2014-2015) participants from The Irish Longitudinal Study on Ageing (TILDA), a large-scale prospective cohort study of individuals aged 50 and over. Of 4309 participants attending for health centre assessment, 578 individuals returned for 3T multi-parametric MRI brain examinations. In total, CBF GM data acquired from 468 subjects using pCASL-MRI were included in this analysis. Normative values were estimated using Generalised Additive Models for Location Shape and Scale (GAMLSS) and are presented as percentiles, means and standard deviations.
Results: The mean age of the cohort was 68.2 ± 6.9 years and 51.7% were female. Mean CBF GM for the cohort was 36.5 ± 8.2 ml/100 g/min. CBF GM decreased by 0.2 ml/100 g/min for each year increase in age (95% CI = -0.3, -0.1; p ≤ 0.001) and was 3.1 ml/100 g/min higher in females (95% CI = 1.6, 4.5; p ≤ 0.001).
Conclusions: This study is by far the largest single-site study focused on an elderly community-dwelling cohort to present normative reference values for CBF GM measured at 3T using pCASL-MRI. Significant age- and sex-related differences exist in CBF GM .
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
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