| Autor: |
Legon'kova OA; A. V. Vishnevsky National Medical Research Centre of Surgery, Ministry of Health of the Russian Federation, Moscow, Russia. oalegonkovapb@mail.ru., Chupin AV; A. V. Vishnevsky National Medical Research Centre of Surgery, Ministry of Health of the Russian Federation, Moscow, Russia., Ogannisian AS; A. V. Vishnevsky National Medical Research Centre of Surgery, Ministry of Health of the Russian Federation, Moscow, Russia., Nikitina AV; A. V. Vishnevsky National Medical Research Centre of Surgery, Ministry of Health of the Russian Federation, Moscow, Russia., Stafford VV; Federal Research Center All-Russian Research Institute of Experimental Veterinary, Russian Academy of Sciences, Moscow, Russia., Savchenkova IP; Federal Research Center All-Russian Research Institute of Experimental Veterinary, Russian Academy of Sciences, Moscow, Russia., Varava AB; A. V. Vishnevsky National Medical Research Centre of Surgery, Ministry of Health of the Russian Federation, Moscow, Russia., Sapelkin SV; A. V. Vishnevsky National Medical Research Centre of Surgery, Ministry of Health of the Russian Federation, Moscow, Russia., Pozyabin SV; K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, Russia. |
| Abstrakt: |
A composition in the form of liquid polymer substance intended for embolization procedures was studied in in vivo experiment. The preparation was injected to rabbits into the femoral artery and abdominal aorta. The polymer composition exhibited properties previously demonstrated in vitro: strong adhesion to the vascular wall, high plasticity sufficient for embolization of the blood vessels, distal distribution, and the absence of toxic effects. The contrast substance remained in the embolus, which simplified its further localization. The agent underwent nether resorption nor organization. Injection of the agent in a volume of 0.1 ml was sufficient for embolization of an artery with a diameter of 0.1 cm. The polymer composition completely obstructed the vessel without inducing perforation of its wall. During the first day of the experiment, a slight infiltration of surrounding tissues with lymphoid cells was observed. By day 7, total dry necrosis of pelvic limb distal to the injection site was diagnosed. Inflammation of the surrounding tissues was shown histologically and was considered as the body response to impaired circulation and necrosis. |
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