The Role of ESR1 Gene Polymorphic Markers in the Development of Breast Cancer and Resistance to Tamoxifen Therapy.

Autor: Lukina SS; Research Institute of General Pathology and Pathophysiology, Moscow, Russia.; I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russian Federation (Sechenov University), Moscow, Russia., Burdennyy AM; Research Institute of General Pathology and Pathophysiology, Moscow, Russia. burdennyy@gmail.com.; N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia. burdennyy@gmail.com., Zavarykina TM; N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia., Riabchikov DA; N. N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russian Federation, Moscow, Russia., Kazubskaya TP; N. N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russian Federation, Moscow, Russia., Kruglova MP; I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russian Federation (Sechenov University), Moscow, Russia., Loginov VI; Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2021 Jan; Vol. 170 (3), pp. 350-355. Date of Electronic Publication: 2021 Jan 16.
DOI: 10.1007/s10517-021-05065-y
Abstrakt: We studied the effect of functionally significant polymorphic markers of the ESR1 gene on the risk of breast cancer, tamoxifen resistance, and survival of patients with this type of cancer. The study included 239 primary breast cancer patients without distant metastases. The analysis of genotype frequency distribution for the studied ESR1 gene polymorphic markers showed the association of the rs2228480 and rs2234693 markers with tamoxifen resistance in the group of patients with luminal B type breast cancer. An association of these two polymorphic markers with the risk of tumor development was also revealed; for rs2234693 polymorphic marker, a relationship with the survival of patients was also showed.
Databáze: MEDLINE
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