Osteoporosis prevention in an extraordinary hibernating bear.

Autor: Donahue SW; Department of Biomedical Engineering, University of Massachusetts, Amherst, United States of America. Electronic address: swdonahue@umass.edu., Wojda SJ; Department of Biomedical Engineering, University of Massachusetts, Amherst, United States of America., McGee-Lawrence ME; Department of Cellular Biology and Anatomy, Department of Orthopaedic Surgery, Medical College of Georgia, Augusta University, United States of America., Auger J; Monte L. Bean Life Science Museum, Brigham Young University, United States of America., Black HL; Department of Plant and Wildlife Sciences, Brigham Young University, United States of America.
Jazyk: angličtina
Zdroj: Bone [Bone] 2021 Apr; Vol. 145, pp. 115845. Date of Electronic Publication: 2021 Jan 13.
DOI: 10.1016/j.bone.2021.115845
Abstrakt: Disuse osteoporosis results from physical inactivity. Reduced mechanical loading of bone stimulates bone resorption leading to bone loss, decreased mechanical properties, and increased fracture risk. Compensatory mechanisms evolved in hibernators to preserve skeletal muscle and bone during the prolonged physical inactivity that occurs during annual hibernation. This paper reports the preservation of bone properties in an exceptionally old black bear that was physically inactive for about 6 months annually for 31 years. The biological mechanisms that preserve bone during prolonged disuse during hibernation are also reviewed.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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