Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.

Autor:	Luongo C; UMR 7221 Phyma, CNRS/Muséum National d'Histoire Naturelle, 75005 Paris, France., Butruille L; UMR 7221 Phyma, CNRS/Muséum National d'Histoire Naturelle, 75005 Paris, France., Sébillot A; UMR 7221 Phyma, CNRS/Muséum National d'Histoire Naturelle, 75005 Paris, France., Le Blay K; UMR 7221 Phyma, CNRS/Muséum National d'Histoire Naturelle, 75005 Paris, France., Schwaninger M; Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, 23562 Lübeck, Germany., Heuer H; Department of Endocrinology, Diabetes and Metabolism, University of Duisburg-Essen, 45122 Essen, Germany., Demeneix BA; UMR 7221 Phyma, CNRS/Muséum National d'Histoire Naturelle, 75005 Paris, France., Remaud S; UMR 7221 Phyma, CNRS/Muséum National d'Histoire Naturelle, 75005 Paris, France. Electronic address: sremaud@mnhn.fr.
Jazyk:	angličtina
Zdroj:	Stem cell reports [Stem Cell Reports] 2021 Feb 09; Vol. 16 (2), pp. 337-353. Date of Electronic Publication: 2021 Jan 14.
DOI:	10.1016/j.stemcr.2020.12.009
Abstrakt:	Adult neural stem cell (NSC) generation in vertebrate brains requires thyroid hormones (THs). How THs enter the NSC population is unknown, although TH availability determines proliferation and neuronal versus glial progenitor determination in murine subventricular zone (SVZ) NSCs. Mice display neurological signs of the severely disabling human disease, Allan-Herndon-Dudley syndrome, if they lack both MCT8 and OATP1C1 transporters, or MCT8 and deiodinase type 2. We analyzed the distribution of MCT8 and OATP1C1 in adult mouse SVZ. Both are strongly expressed in NSCs and at a lower level in neuronal cell precursors but not in oligodendrocyte progenitors. Next, we analyzed Mct8/Oatp1c1 double-knockout mice, where brain uptake of THs is strongly reduced. NSC proliferation and determination to neuronal fates were severely affected, but not SVZ-oligodendroglial progenitor generation. This work highlights how tight control of TH availability determines NSC function and glial-neuron cell-fate choice in adult brains. (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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