[Comparison of the efficacy of Cellex and Cortexin in patients in the early recovery period of ischemic stroke].

Autor:	Khabirov FA; Kazan State Medical Academy, Kazan, Russia.; Republic Clinical Neurology Center, Kazan, Russia., Khaibullin TI; Kazan State Medical Academy, Kazan, Russia.; Republic Clinical Neurology Center, Kazan, Russia., Granatov EV; Republic Clinical Neurology Center, Kazan, Russia., Akhmetova GI; Republic Clinical Neurology Center, Kazan, Russia., Akhmetzyanov NM; Republic Clinical Neurology Center, Kazan, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2020; Vol. 120 (12. Vyp. 2), pp. 11-15.
DOI:	10.17116/jnevro202012012211
Abstrakt:	Objective: To compare the efficacy of Cellex and Cortexin in patients in the early recovery period of ischemic stroke (ERPIS) receiving basic therapy (BT). Material and Methods: Forty patients were randomized into the cellex group ( n =20) and the cortexin group 2 ( n =20). Cellex was administered in a dose of 0.1 mg daily SC for 10 days and cortexin in a dose of 10 mg per 2 ml of 0.9% NaCl solution IM daily for 10 days. The efficacy of treatment was assessed with NIHSS, Bartel's index (BI), MMSE, the Rivermead Mobility Index (RMI), the Frontal Assessment Battery (FAB), Beck's depression scale (BDS). Results: A more pronounced positive dynamics of NIHSS: 3 [2; 4.5] vs. 5 [2; 7] ( p =0.03) and MMSE scores: 24 [21.5; 25] vs. 22 [20; 23] ( p =0.04) was noted in the cellex group. Also, in this group, a more significant trend towards regression of depressive disorders (BDS) was revealed: 17.5 [14.5; 21] vs. 14 [13; 16] ( p =0.064). The dynamics of RMI and FAB scores did not differ significantly between the groups. Conclusion: The use of cellex in comparison with cortexin is more effective in terms of the dynamics of regression of neurological and neurocognitive dysfunctions in patients with ERPIS.
Databáze:	MEDLINE
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