| Autor: |
Mac Giollabhui N; Department of Psychology, Temple University, Philadelphia, PA, USA. naoise.macgiollabhui@temple.edu., Alloy LB; Department of Psychology, Temple University, Philadelphia, PA, USA., Swistun D; Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA., Coe CL; Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA., Ellman LM; Department of Psychology, Temple University, Philadelphia, PA, USA., Moriarity DP; Department of Psychology, Temple University, Philadelphia, PA, USA., Stumper AC; Department of Psychology, Temple University, Philadelphia, PA, USA., Abramson LY; Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA. |
| Abstrakt: |
Chronic, systemic inflammation is implicated in physical and mental health; little is known about whether sex and racial differences detected in adulthood are observed during adolescence or about normative changes occurring during adolescence. This longitudinal, United States-based study examined four biomarkers of systemic inflammation [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and IL-8) in 315 adolescents (51% female; 58% black; baseline age = 16.49 years (SD = 1.56; range: 12.14-21.28)] at three timepoints. Notable results included: general decline in inflammatory biomarkers in older adolescents, lower levels of TNF-α/IL-8 in black adolescents, elevated CRP/IL-6 in females, and especially higher levels of IL-6 in black, female adolescents. Implications are discussed, particularly the potential health implications of elevated IL-6 in black females. |
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