Modeling transfer of vaginal microbiota from mother to infant in early life.

Autor: Mortensen MS; Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Rasmussen MA; Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen University Hospital Gentofte, Hellerup, Denmark.; Department of Food Science, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark., Stokholm J; Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen University Hospital Gentofte, Hellerup, Denmark., Brejnrod AD; Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Balle C; Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Thorsen J; Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen University Hospital Gentofte, Hellerup, Denmark., Krogfelt KA; Virus & Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark.; Department of Science and Environment, Roskilde University, Roskilde, Denmark., Bisgaard H; Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen University Hospital Gentofte, Hellerup, Denmark., Sørensen SJ; Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: ELife [Elife] 2021 Jan 15; Vol. 10. Date of Electronic Publication: 2021 Jan 15.
DOI: 10.7554/eLife.57051
Abstrakt: Early-life microbiota has been linked to the development of chronic inflammatory diseases. It has been hypothesized that maternal vaginal microbiota is an important initial seeding source and therefore might have lifelong effects on disease risk. To understand maternal vaginal microbiota's role in seeding the child's microbiota and the extent of delivery mode-dependent transmission, we studied 665 mother-child dyads from the COPSAC 2010 cohort. The maternal vaginal microbiota was evaluated twice in the third trimester and compared with the children's fecal (at 1 week, 1 month, and 1 year of age) and airway microbiota (at 1 week, 1 month, and 3 months). Based on the concept of weighted transfer ratios (WTRs), we have identified bacterial orders for which the WTR displays patterns indicate persistent or transient transfer from the maternal vaginal microbiome, as well as orders that are shared at later time points independent of delivery mode, indicating a common reservoir.
Competing Interests: MM, MR, JS, AB, CB, JT, KK, HB, SS No competing interests declared
(© 2021, Mortensen et al.)
Databáze: MEDLINE
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