Embryonal Tumor With Multilayered Rosettes of the Parietooccipital Region: A Case Report.
| Autor: | Horwitz J; Faculty of Medicine, University of Ottawa., Huang A; Division of Pediatric Hematology/Oncology, Hospital for Sick Children, Toronto, Canada., McAuley D; Divisions of Pediatric Neurosurgery., Jansen GH; Divisin of Anatomical Pathology, Eastern Ontario Regional Laboratory Association, Ottawa, ON., Johnston D; Pediatric Hematology/Oncology, Children's Hospital of Eastern Ontario. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2022 Jan 01; Vol. 44 (1), pp. e255-e259. |
| DOI: | 10.1097/MPH.0000000000002048 |
| Abstrakt: | Embryonal tumor with multilayered rosettes is a rare and highly malignant early childhood brain tumor. We report a case of embryonal tumor with multilayered rosettes in the parietooccipital region of a 2-year-old girl. Histopathology of the tumor demonstrated amplification of the 19q13.42 locus and strong positivity for LIN28A. Treatment was multimodal and included 3 surgical resections, adjuvant chemotherapy with autologous stem cell rescue, and focal radiotherapy. The use of the agents vorinostat and isotretinoin, and the addition of focal radiation have not been extensively described in this patient population, but may attribute to our patient's sustained remission at 2.5-years follow-up. Competing Interests: The authors declare no conflict of interest. (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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