Association between thiamine deficiency and hyperlactatemia among critically ill patients with diabetes infected by SARS-CoV-2.

Autor: Gonçalves SEAB; Sancta Maggiore Hospital, Prevent Senior Private Health Operator, São Paulo, Brazil., Gonçalves TJM; Sancta Maggiore Hospital, Prevent Senior Private Health Operator, São Paulo, Brazil., Guarnieri A; Sancta Maggiore Hospital, Prevent Senior Private Health Operator, São Paulo, Brazil., Risegato RC; Sancta Maggiore Hospital, Prevent Senior Private Health Operator, São Paulo, Brazil., Guimarães MP; Sancta Maggiore Hospital, Prevent Senior Private Health Operator, São Paulo, Brazil., de Freitas DC; Sancta Maggiore Hospital, Prevent Senior Private Health Operator, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Journal of diabetes [J Diabetes] 2021 Jan 15. Date of Electronic Publication: 2021 Jan 15.
DOI: 10.1111/1753-0407.13156
Abstrakt: Background: The present study aims to verify the association between diabetes and thiamine deficiency in critically ill patients infected by severe acute respiratory syndrome coronavirus 2.
Methods: This is a descriptive cross-sectional study, whose demographic, anthropometric, and laboratory data (arterial lactate, bicarbonate, and plasma thiamine) were obtained in the first hours of admission to the intensive care unit. Patients with diabetes were compared with individuals without diabetes, and the correlation was performed between thiamine and lactate levels. Thiamine levels <28 μg/L were considered as thiamine deficiency.
Results: Overall, 270 patients met the inclusion criteria; 51.1% were men, and the median age was 74 years (66.8-81). The median value of thiamine was 54.0 μg/L (38-72.3), and 15.6% had thiamine deficiency. Among patients with diabetes, 26.3% had thiamine deficiency, and 69.3% had hyperlactatemia. There was an association between thiamine deficiency and diabetes (odds ratio 4.28; 95% CI, 2.08-8.81; P < .001). There was a strong negative correlation between thiamine and arterial lactate in patients with diabetes (r = -0.711, P < .001) and a moderate negative correlation in critically ill patients without diabetes (r = -0.489, P < .001).
Conclusions: The prevalence of thiamine deficiency in critically ill patients due to coronavirus disease 2019 is higher in patients with diabetes. There is a negative correlation between thiamine and arterial lactate levels, which is higher in people with diabetes.
(© 2021 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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