Spatial correspondence of spinal cord white matter tracts using diffusion tensor imaging, fibre tractography, and atlas-based segmentation.

Autor: McLachlin S; Department of Mechanical and Mechatronics Engineering, University of Waterloo, 200 University Avenue West, E7 3424, Waterloo, Ontario, N2L 3G1, Canada., Leung J; Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, 2075 Bayview Ave, S621, Toronto, Ontario, M4N 3M5, Canada., Sivan V; Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, 2075 Bayview Ave, S621, Toronto, Ontario, M4N 3M5, Canada., Quirion PO; Department of Electrical Engineering, Polytechnique Montreal, Ecole Polytechnique, Pavillon Lassonde, 2700 Ch de la Tour, L-5610, Montréal, Quebec, H3T 1N8, Canada., Wilkie P; Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, 2075 Bayview Ave, S621, Toronto, Ontario, M4N 3M5, Canada., Cohen-Adad J; Department of Electrical Engineering, Polytechnique Montreal, Ecole Polytechnique, Pavillon Lassonde, 2700 Ch de la Tour, L-5610, Montréal, Quebec, H3T 1N8, Canada., Whyne CM; Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, 2075 Bayview Ave, S621, Toronto, Ontario, M4N 3M5, Canada.; Department of Surgery, University of Toronto, 2075 Bayview Ave, S621, Toronto, Ontario, M4N 3M5, Canada., Hardisty MR; Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, 2075 Bayview Ave, S621, Toronto, Ontario, M4N 3M5, Canada. michael.hardisty@sunnybrook.ca.; Department of Surgery, University of Toronto, 2075 Bayview Ave, S621, Toronto, Ontario, M4N 3M5, Canada. michael.hardisty@sunnybrook.ca.
Jazyk: angličtina
Zdroj: Neuroradiology [Neuroradiology] 2021 Mar; Vol. 63 (3), pp. 373-380. Date of Electronic Publication: 2021 Jan 14.
DOI: 10.1007/s00234-021-02635-9
Abstrakt: Purpose: Neuroimaging provides great utility in complex spinal surgeries, particularly when anatomical geometry is distorted by pathology (tumour, degeneration, etc.). Spinal cord MRI diffusion tractography can be used to generate streamlines; however, it is unclear how well they correspond with white matter tract locations along the cord microstructure. The goal of this work was to evaluate the spatial correspondence of DTI tractography with anatomical MRI in healthy anatomy (where anatomical locations can be well defined in T1-weighted images).
Methods: Ten healthy volunteers were scanned on a 3T system. T1-weighted (1 × 1 × 1 mm) and diffusion-weighted images (EPI readout, 2 × 2 × 2 mm, 30 gradient directions) were acquired and subsequently registered (Spinal Cord Toolbox (SCT)). Atlas-based (SCT) anatomic label maps of the left and right lateral corticospinal tracts were identified for each vertebral region (C2-C6) from T1 images. Tractography streamlines were generated with a customized approach, enabling seeding of specific spinal tract regions corresponding to individual vertebral levels. Spatial correspondence of generated fibre streamlines with anatomic tract segmentations was compared in unseeded regions of interest (ROIs).
Results: Spatial correspondence of the lateral corticospinal tract streamlines was good over a single vertebral ROI (Dice's similarity coefficient (DSC) = 0.75 ± 0.08, Hausdorff distance = 1.08 ± 0.17 mm). Over larger ROI, fair agreement between tractography and anatomical labels was achieved (two levels: DSC = 0.67 ± 0.13, three levels: DSC = 0.52 ± 0.19).
Conclusion: DTI tractography produced good spatial correspondence with anatomic white matter tracts, superior to the agreement between multiple manual tract segmentations (DSC ~ 0.5). This supports further development of spinal cord tractography for computer-assisted neurosurgery.
Databáze: MEDLINE
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