Striatal Dopaminergic Deficit and Sleep in Idiopathic Rapid Eye Movement Behaviour Disorder: An Explorative Study.

Autor:	Wasserman D; Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.; Sleep Disorders Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK., Bindman D; Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK., Nesbitt AD; Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.; Sleep Disorders Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.; Headache Group, Department of Clinical Neurosciences, King's College Hospital NHS Foundation Trust, London, UK., Cash D; BRAIN, Department of Neuroimaging, King's College London, London, UK., Milosevic M; School of Public Health 'Andrija Stampar', University of Zagreb School of Medicine, Zagreb, Croatia., Francis PT; Wolfson Centre for Age-Related Diseases, King's College London, London, UK., Chaudhuri KR; Movement Disorders Unit, King's College Hospital, Department of Clinical and Basic Neurosciences, Institute of Psychiatry, Psychology & Neuroscience, Parkinson Foundation Centre of Excellence, King's College London, London, UK., Leschziner GD; Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.; Sleep Disorders Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK., Ferini-Strambi L; Sleep Disorders Center, Department of Clinical Neurosciences, Università Vita-Salute San Raffaele, Milan, Italy., Ballard C; Medical School, University of Exeter, Exeter, UK., Eccles A; Department of Nuclear Medicine, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Rosenzweig I; Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.; Sleep Disorders Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Jazyk:	angličtina
Zdroj:	Nature and science of sleep [Nat Sci Sleep] 2021 Jan 06; Vol. 13, pp. 1-9. Date of Electronic Publication: 2021 Jan 06 (Print Publication: 2021).
DOI:	10.2147/NSS.S267037
Abstrakt:	Introduction: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is increasingly recognised as an important precursor disease state of alpha-synucleinopathies. This parasomnia is characterized by a history of recurrent nocturnal dream enactment behaviour, loss of skeletal muscle atonia, and increased phasic muscle activity during REM sleep. Neuroimaging studies of striatal dopamine transporter uptake tracer signaling suggest increasing dopaminergic deficit across the continuum of the alpha-synucleinopathies, with early sleep dysfunction suggestive of early caudate dysfunction. Henceforth, we set out to investigate the relationship between early sleep changes and the striatal dopaminergic availability in iRBD. Methods: Twelve patients with iRBD, who had undergone a video polysomnography and a neuroimaging assessment of striatal dopamine transporter (DaT) uptake tracer signaling, and 22 matched controls who had similarly undergone a video polysomnography were retrospectively identified. Data were statistically analyzed to identify altered sleep parameters and correlate them with striatal dopamine transporter uptake tracer signaling. Results: The iRBD patients exhibited an increased number of periodic limb movements during sleep ( P =0.001), compared to 22 age-matched healthy subjects. In addition, several significant links were found between regional DaT-uptakes and sleep architecture. Correlational analyses suggested a strong positive association between sleep fragmentation and dopamine deficiency in left caudate (r=-0.630, P =0.028), whilst an increased uptake in the whole striatum was strongly linked to the sleep efficiency, and to a lesser degree to the length of sleep duration. Discussion: To the best of our knowledge, this is the first demonstration of a close relationship between dopaminergic availability in striatum and the quality of sleep in iRBD. Taken together, our exploratory findings suggest that subtle but functionally significant striatal changes in early stages of iRBD may contribute to the further shaping of sleep architecture. Competing Interests: Clive Ballard reports grants and personal fees from Acadia, Lundbeck, Novo Nordisk, Synexus, and personal fees from Roche, Otsuka, Biogen, Eli Lilly, AARP, and Sunovion, outside the submitted work. Ivana Rosenzweig reports grants from Wellcome Trust, during the conduct of the study. Ray Chaudhuri reports  personal fees from AbbVie, UCB, GKC, Bial, Cynapsus, Lobsor, Stada, Medtronic, Zambon, Profile, Sunovion, Roche, Therevance, Scion, Britannia, Acadia, 4D (advisory board); honoraria for lectures from AbbVie, Britannia, UCB, Zambon, Novartis, Boeringer Ingelheim, Bial and grants from Britania Pharmaceuticals, AbbVie, UCB, GKC, Bial, EU, IMI EU, Horizon 2020, Parkinson's UK, NIHR, PDNMG, EU (Horizon 2020), Kirby Laing Foundation, NPF, MRC, Wellcome Trust. The authors report no other potential conflicts of interest for this work. (© 2021 Wasserman et al.)
Databáze:	MEDLINE
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