Gut priming with bovine colostrum and T regulatory cells in preterm neonates: a randomized controlled trial.

Autor: Ismail RIH; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Awad HA; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Imam SS; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Gad GI; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Aboushady NM; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Abdou RM; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Eissa DS; Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Azzam NT; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Barakat MM; Ministry of Health, Cairo, Egypt., Yassin MM; Ministry of Health, Cairo, Egypt., Barakat NM; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. noha.m.barakat@med.asu.edu.eg.
Jazyk: angličtina
Zdroj: Pediatric research [Pediatr Res] 2021 Sep; Vol. 90 (3), pp. 650-656. Date of Electronic Publication: 2021 Jan 14.
DOI: 10.1038/s41390-020-01344-y
Abstrakt: Background: Necrotizing enterocolitis (NEC) and neonatal sepsis are still considered major problems, especially in formula-fed preterm neonates. This study aimed to investigate the effect of bovine colostrum on T regulatory cells, NEC, and late-onset sepsis in preterm neonates ≤34 weeks.
Methods: This prospective double-blind randomized controlled trial was conducted on 80 preterm infants who were randomly assigned to either the bovine colostrum group (n = 32) or control group (n = 48). T lymphocytes and their subsets, necrotizing enterocolitis, late-onset sepsis (LOS) and its severity, feeding tolerance, growth, length of hospital stay, and mortality were documented.
Results: The bovine colostrum group showed higher follow-up levels of CD4+CD25+ FOXP3+ T lymphocyte % (FOXP3 Tregs). FOXP3 Tregs and its difference in change levels between baseline and follow-up were considered as the most related factors to the bovine colostrum. Bovine colostrum group showed positive trends for reduction of sepsis severity and mortality with no significant difference in the incidence of NEC, LOS, and length of hospital stay.
Conclusions: Preterm neonates who received bovine colostrum showed a higher FOXP3 Treg level.
Impact: Bovine colostrum has no significant effect on the incidence of necrotizing enterocolitis. FOXP3 T regulatory cells and their increased level between baseline and follow-up is considered as the most influencing factors related to the bovine colostrum. Positive trends were noted for reduction of sepsis severity and concomitant mortality, but the study lacked the power to assess these outcomes.
(© 2021. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)
Databáze: MEDLINE
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