Polyol-Silk Bioink Formulations as Two-Part Room-Temperature Curable Materials for 3D Printing.

Autor:	Jose RR; Department of Biomedical Engineering, Tufts University Science and Technology, Center 4 Colby Street, Medford, Massachusetts 02155, United States., Brown JE; Department of Biomedical Engineering, Tufts University Science and Technology, Center 4 Colby Street, Medford, Massachusetts 02155, United States., Polido KE; Department of Biomedical Engineering, Tufts University Science and Technology, Center 4 Colby Street, Medford, Massachusetts 02155, United States., Omenetto FG; Department of Biomedical Engineering, Tufts University Science and Technology, Center 4 Colby Street, Medford, Massachusetts 02155, United States., Kaplan DL; Department of Biomedical Engineering, Tufts University Science and Technology, Center 4 Colby Street, Medford, Massachusetts 02155, United States.
Jazyk:	angličtina
Zdroj:	ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2015 Sep 14; Vol. 1 (9), pp. 780-788. Date of Electronic Publication: 2015 Aug 14.
DOI:	10.1021/acsbiomaterials.5b00160
Abstrakt:	Silk-based bioinks were developed for 2D and 3D printing. By incorporating nontoxic polyols into silk solutions, two-part formulations with self-curing features at room temperature were generated. By varying the formulations the crystallinity of the silk polymer matrix could be controlled to support printing in 2D and 3D formats interfaced with CAD geometry and with good feature resolution. The self-curing phenomenon was tuned and exploited in order to demonstrate the formation of both structural and support materials. Biocompatible aqueous protein inks for printing that avoid the need for chemical or photo initiators and that form aqueous-stable structures with good resolution at ambient temperatures provide useful options for biofunctionalization and a broad range of applications.
Databáze:	MEDLINE
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