Is there a place for measuring serum calcitonin prior to thyroidectomy in patients with a non-diagnostic thyroid nodule biopsy?

Autor:	de Oliveira DHA; Serviço de Endocrinologia e Metabologia, Hospital de Clínicas, Universidade Federal do Paraná (SEMPR), Curitiba, PR, Brasil, diegohenrique1405@yahoo.com.br., Huning LP; Universidade Estadual do Oeste do Paraná (Unioeste), Cascavel, PR, Brasil., Belim MC; Universidade Estadual do Oeste do Paraná (Unioeste), Cascavel, PR, Brasil., Rodrigues PF; Universidade Estadual do Oeste do Paraná (Unioeste), Cascavel, PR, Brasil., Nagai HM; União Oeste Paranaense de Estudos e Combate ao Câncer (Uopeccan), Cascavel, PR, Brasil., Graf H; Serviço de Endocrinologia e Metabologia, Hospital de Clínicas, Universidade Federal do Paraná (SEMPR), Curitiba, PR, Brasil.
Jazyk:	angličtina
Zdroj:	Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2021 Nov 01; Vol. 65 (1), pp. 40-48. Date of Electronic Publication: 2021 Jan 14.
DOI:	10.20945/2359-3997000000320
Abstrakt:	Objective: To verify the cytopathological Bethesda System classification of thyroid nodule fine-needle aspiration biopsy (FNAB) in MTC patients and to assess the role of preoperative serum calcitonin (CT) levels in the investigation of this neoplasm in medullary thyroid cancer (MTC) patients under observation at the Uopeccan ( União Oeste Paranaense de Estudos e Combate ao Câncer ). Methods: This is a cross-sectional review of medical records of patients monitored at the thyroid cancer outpatient clinic of Uopeccan. Clinical and demographic data, laboratory tests, ultrasound images, and cytopathological findings of MTC patients were evaluated. Results: Among the 360 patients with thyroid cancer monitored in the outpatient clinic, 5.2% (n: 19/360) had MTC. The hereditary form was more prevalent (63.2%), and there was no sex preference. The most common ultrasound findings were hypoechogenicity, solid appearance and microcalcifications. The FNAB diagnoses showed a sensitivity of 47.1%, and the most common cytopathological report was Bethesda category III. Serum CT levels showed good sensitivity (84.6%) for the diagnosis of MTC, and sensitivity levels were directly associated with the size of the nodule and distant metastases. Conclusion: Bethesda category III was more prevalent in this group of MTC patients. Serum CT levels were more sensitive than cytopathology for diagnosis of this neoplasm and were able to identify all patients who could not be diagnosed by FNAB.
Databáze:	MEDLINE
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