| Autor: |
Demey L; Chest Department, Erasme University Hospital, Université libre de Bruxelles, Brussels, Belgium., Van Muylem A; Chest Department, Erasme University Hospital, Université libre de Bruxelles, Brussels, Belgium., Malinovschi A; Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden., Haccuria A; Chest Department, Erasme University Hospital, Université libre de Bruxelles, Brussels, Belgium., Perez-Bogerd S; Chest Department, Erasme University Hospital, Université libre de Bruxelles, Brussels, Belgium., Michils A; Chest Department, Erasme University Hospital, Université libre de Bruxelles, Brussels, Belgium. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2021 Apr 01; Vol. 130 (4), pp. 1106-1113. Date of Electronic Publication: 2021 Jan 14. |
| DOI: |
10.1152/japplphysiol.00643.2020 |
| Abstrakt: |
We previously documented, in patients with asthma, three different profiles of bronchodilation induced by short-acting β-2 mimetics (SABA), characterized by dilation up to central, preacinar, and intra-acinar airways assessed by ventilation distribution tests and associated with no change, increase, and decrease of fractional exhaled nitric oxide concentration (FENO), respectively. To investigate the dynamics of these profiles over the entire SABA action period, assuming that bronchodilation of proximal and peripheral airways could exhibit varying kinetics due to differences in the distribution of β-2 receptors in both the central and peripheral human airways. FENO, forced expired volume in one second (FEV 1 ), and the slope ( S ) of He and SF 6 phase III (single-breath test) were measured in asthma patients before, and up to 6 h after SABA inhalation (salbutamol 400 µg). S He and S SF6 decrease reflects pre- and intra-acinar obstruction relief, respectively. Thirty patients with asthma (12F/18M, aged 45 ± 18 yr) were divided into groups with positive (NO+, n = 9), negative (NO-, n = 11), and no (NO=, n = 10) FENO acute change. In the NO- group, FEV 1 increased for up to 4 h, whereas FENO, S He , and S F6 decreased in the early phase only. In stark contrast, in the NO+ group, FEV 1 increased in the early phase only whereas the FENO increase and the S He decrease lasted for up to 4 h. This study documents various profiles of SABA-induced bronchodilation in patients with asthma, differing both by sites and dynamics of the bronchodilator process. So, detailed understanding of the bronchodilator effect of β2-agonists in asthma should not solely be limited to studying their impact on FEV 1 . NEW & NOTEWORTHY FEV 1 increase usually observed after the inhalation of short-acting β2-agonists in asthma patients tends to involve peripheral airways. This study shows that the heterogeneity of responses to short-acting β2-agonists in asthma not only involves distinct sites of bronchodilation, but also distinct sequences between these sites. This indicates that a detailed understanding of the bronchodilator effect of β2-agonists in asthma should not be limited to studying its early impact on FEV 1 . |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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