An early experience on the effect of solid organ transplant status on hospitalized COVID-19 patients.

Autor: Nair V; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York., Jandovitz N; North Shore University Hospital, Northwell Health, Manhasset, New York., Hirsch JS; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Information Services, Northwell Health, New Hyde Park, New York., Abate M; Department of Surgery, Northwell Health, Manhasset, New York., Satapathy SK; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York., Roth N; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York., Miyara SJ; North Shore University Hospital, Northwell Health, Manhasset, New York.; Department of Surgery, Northwell Health, Manhasset, New York., Guevara S; Department of Surgery, Northwell Health, Manhasset, New York., Kressel AM; Department of Surgery, Northwell Health, Manhasset, New York., Xiang A; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York., Wu G; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York., Butensky SD; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York., Lin D; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York., Williams S; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York., Bhaskaran MC; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York., Majure DT; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.; North Shore University Hospital, Northwell Health, Manhasset, New York., Grodstein E; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York., Lau L; North Shore University Hospital, Northwell Health, Manhasset, New York.; Long Island Jewish Medical Center, Northwell Health, New Hyde Park, New York., Nair G; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York., Fahmy AE; North Shore University Hospital, Northwell Health, Manhasset, New York., Winnick A; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.; Department of Surgery, Northwell Health, Manhasset, New York., Breslin N; North Shore University Hospital, Northwell Health, Manhasset, New York., Berlinrut I; North Shore University Hospital, Northwell Health, Manhasset, New York.; Long Island Jewish Medical Center, Northwell Health, New Hyde Park, New York., Molmenti C; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Becker LB; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.; North Shore University Hospital, Northwell Health, Manhasset, New York.; Long Island Jewish Medical Center, Northwell Health, New Hyde Park, New York., Malhotra P; North Shore University Hospital, Northwell Health, Manhasset, New York.; Long Island Jewish Medical Center, Northwell Health, New Hyde Park, New York., Gautam-Goyal P; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York., Lima B; North Shore University Hospital, Northwell Health, Manhasset, New York., Maybaum S; North Shore University Hospital, Northwell Health, Manhasset, New York., Shah SK; North Shore University Hospital, Northwell Health, Manhasset, New York., Takegawa R; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Hayashida K; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Shinozaki K; North Shore University Hospital, Northwell Health, Manhasset, New York.; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Long Island Jewish Medical Center, Northwell Health, New Hyde Park, New York., Teperman LW; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York., Molmenti EP; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
Jazyk: angličtina
Zdroj: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2021 Jul; Vol. 21 (7), pp. 2522-2531. Date of Electronic Publication: 2021 Jan 13.
DOI: 10.1111/ajt.16460
Abstrakt: We compared the outcome of COVID-19 in immunosuppressed solid organ transplant (SOT) patients to a transplant naïve population. In total, 10 356 adult hospital admissions for COVID-19 from March 1, 2020 to April 27, 2020 were analyzed. Data were collected on demographics, baseline clinical conditions, medications, immunosuppression, and COVID-19 course. Primary outcome was combined death or mechanical ventilation. We assessed the association between primary outcome and prognostic variables using bivariate and multivariate regression models. We also compared the primary endpoint in SOT patients to an age, gender, and comorbidity-matched control group. Bivariate analysis found transplant status, age, gender, race/ethnicity, body mass index, diabetes, hypertension, cardiovascular disease, COPD, and GFR <60 mL/min/1.73 m 2 to be significant predictors of combined death or mechanical ventilation. After multivariate logistic regression analysis, SOT status had a trend toward significance (odds ratio [OR] 1.29; 95% CI 0.99-1.69, p = .06). Compared to an age, gender, and comorbidity-matched control group, SOT patients had a higher combined risk of death or mechanical ventilation (OR 1.34; 95% CI 1.03-1.74, p = .027).
(© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.)
Databáze: MEDLINE
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