Stereospecific Cross-Coupling Reactions Provide Conformationally-Biased Arylalkanes with Anti-Leukemia Activity.

Autor:	Sanford AB; Department of Chemistry, University of California, Irvine, Natural Sciences II, Irvine, CA, 92697., Tollefson EJ; Department of Chemistry, University of California, Irvine, Natural Sciences II, Irvine, CA, 92697., Jarvo ER; Department of Chemistry, University of California, Irvine, Natural Sciences II, Irvine, CA, 92697.
Jazyk:	angličtina
Zdroj:	Israel journal of chemistry [Isr J Chem] 2020 Mar; Vol. 60, pp. 402-405. Date of Electronic Publication: 2019 Sep 06.
DOI:	10.1002/ijch.201900071
Abstrakt:	A focused small library of carbamates and alcohols was prepared employing stereospecific Kumada-ring opening reactions of tetrahydropyrans. The core framework of the library members is acyclic and incorporates 1,3-substituents, to provide a conformational bias in avoiding syn-pentane interactions. A new compound with micromolar activity against MOLT-4, CCRF-CEM, and HL-60(TB) leukemia cell lines was identified from this series.
Databáze:	MEDLINE
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