Safety assessment of genetically modified rice expressing Cry1Ab protein in Sprague-Dawley rats.

Autor: Hajimohammadi B; Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Islamic Republic of Iran., Eslami G; Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Islamic Republic of Iran. eslami_g2000@yahoo.com., Zandi H; Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Islamic Republic of Iran., Ehrampoush MH; Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Islamic Republic of Iran., Naimi A; Department of Pathology, Medical University of Isfahan, Isfahan, Iran., Derakhshan M; Department of Pathology, Medical University of Isfahan, Isfahan, Iran., Hedayat P; Department of Pathology, Medical University of Isfahan, Isfahan, Iran., Fallahi R; Animal Viral Diseases Research Department, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), 3197619751, Karaj, Iran., Fallahzadeh H; Department of Biostatistics and Epidemiology, Daneshjoo Boulevard, Health School, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blv., Yazd, 8916188638, Islamic Republic of Iran., Rezvani ME; Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Islamic Republic of Iran., Vakili M; Department of Community and Preventive Medicine, Health Monitoring Research Center, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blv., Yazd, 8916188638, Islamic Republic of Iran., Moshtaghioun SM; Department of Biology, Faculty of Sciences, Yazd University, Yazd, Iran., Athari SS; Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran., Asadi-Yousefabad SL; Department of Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Islamic Republic of Iran., Hosseini SS; Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Islamic Republic of Iran., Shirdeli M; Department of Food Science and Technology, Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran., Ahmadian S; Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Islamic Republic of Iran., Mortazavi S; Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Islamic Republic of Iran., Loni E; Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Islamic Republic of Iran., Ajamein V; Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Islamic Republic of Iran., Ahmadi A; Department of Pathobiology, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran., Askari V; Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Islamic Republic of Iran.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Jan 13; Vol. 11 (1), pp. 1126. Date of Electronic Publication: 2021 Jan 13.
DOI: 10.1038/s41598-021-80958-6
Abstrakt: Rice is considered one of the most important staple food crops. Genetically modified (GM) Bt rice, harbored cry1Ab gene expressing the insect-resistance protein has been developed to resistance to the insects. In this study, we assessed the safety of the GM Bt rice on Sprague-Dawley rats for 90 days. Totally, 120 rats in both sexes were used for three different diets, including 50% GM Bt rice, feeding with 50% rice, and standard feeding. Each 40 SD rats including 20 males and 20 females were considered as each diet. The clinical variables such as body weight and food consumption were measured and a range of clinical tests was examined, including hematology, serum chemistry parameters, urinalysis profile, thyroid, and sex hormone levels. Pathological assessments were also done. The results showed that the mean weekly feed utilization (%) had no significant difference among the studied groups. Also, blood biochemistry, hematological parameters, urine analysis, and hormonal levels had no significant differences among the groups. However, alanine aminotransferase was less in males versus female feeding with GM Bt rice. No histopathological changes were observed among the groups. In conclusion, this study demonstrated that GM Bt rice had no obvious adverse effects on rats' health.
Databáze: MEDLINE
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