Scaffolds--The Ground for Regeneration: A Narrative Review.

Autor:	Joshi SR; Department of Pediatric & Preventive Dentistry, Rural Dental College, Loni, Maharashtra, India., Pendyala GS; Department of Peridontics, Rural Dental College, Loni, Maharashtra, India., Shah P; Department of Pediatric & Preventive Dentistry, Rural Dental College, Loni, Maharashtra, India., Mopagar VP; Department of Pediatric & Preventive Dentistry, Rural Dental College, Loni, Maharashtra, India., Padmawar N; Department of Pediatric & Preventive Dentistry, Rural Dental College, Loni, Maharashtra, India., Padubidri M; Department of Pediatric & Preventive Dentistry, Rural Dental College, Loni, Maharashtra, India.
Jazyk:	angličtina
Zdroj:	Journal of International Society of Preventive & Community Dentistry [J Int Soc Prev Community Dent] 2020 Nov 24; Vol. 10 (6), pp. 692-699. Date of Electronic Publication: 2020 Nov 24 (Print Publication: 2020).
DOI:	10.4103/jispcd.JISPCD_198_20
Abstrakt:	Aim: The aim of this study was to comprehensively review the various biomaterials used as scaffolds, rates of biodegradability of natural, artificial and composite hybrid scaffolds, and the role of controlled biodegradability in tissue engineering. Materials and Methods: An electronic search for systematic review was conducted in PubMed/MEDLINE (www.ncbi.nlm.nih.gov), Cochrane (www.cochrane.org), Scopus (www.scopus.com) databases, and dental journals related to endodontics and pediatric dentistry to identify the research investigations associated with the degradation profiles, factors relating to degradation, rates of biodegradability and the role of controlled biodegradability of natural, artificial and composite scaffolds. A sample of 17 relevant studies and case reports were identified in our search of 100 using simple random sampling. Results: Naturally derived scaffolds degrade at a much higher rate than artificial and composite scaffolds. The degradation profiles of composite scaffolds can be much better controlled than naturally derived scaffolds. Conclusion: Composite scaffolds are more favorable as compared to natural or artificial scaffolds, as it has superior mechanical properties, minimal immune response, and a controlled rate of degradation and consequent tissue regeneration. Competing Interests: There are no conflicts of interest. (Copyright: © 2020 Journal of International Society of Preventive and Community Dentistry.)
Databáze:	MEDLINE
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