Mortality and glycemic control among patients with acute and chronic myeloid leukemia and diabetes: a case-control study.

Autor: Wiedmeier JE; Department of Internal Medicine, Mayo Clinic Hospital, 5777 E Mayo Blvd, Phoenix, AZ 85054, USA., Mountjoy LJ; Division of Hematology & Medical Oncology, Mayo Clinic Hospital, 5777 E Mayo Blvd, Phoenix, AZ 85054, USA.; Colorado Blood Cancer Institute, 1721 E 19th Ave, Suites 200-300, Denver, CO 80218, USA., Buras MR; Biostatistics, Mayo Clinic, 13400 E. SheaBlvd., Scottsdale, AZ 85259, USA., Kosiorek HE; Biostatistics, Mayo Clinic, 13400 E. SheaBlvd., Scottsdale, AZ 85259, USA., Coppola KE; Mayo Clinic Cancer Center, Mayo Clinic, 13400 E. Shea Blvd., Scottsdale, AZ 85259, USA., Verona PM; Enterprise Technology Services, Mayo Clinic Hospital, 5777 E Mayo Blvd, Phoenix, AZ 85054, USA., Cook CB; Division of Endocrinology, Mayo Clinic, 13400 E. Shea Blvd., Scottsdale, AZ 85259, USA., Karlin NJ; Division of Hematology & Medical Oncology, Mayo Clinic Hospital, 5777 E Mayo Blvd, Phoenix, AZ 85054, USA.; Mayo Clinic Cancer Center, Mayo Clinic, 13400 E. Shea Blvd., Scottsdale, AZ 85259, USA.
Jazyk: angličtina
Zdroj: Future science OA [Future Sci OA] 2020 Oct 26; Vol. 7 (1), pp. FSO639. Date of Electronic Publication: 2020 Oct 26.
DOI: 10.2144/fsoa-2020-0117
Abstrakt: Aim: We examined the association between diabetes and survival in patients with acute and chronic myeloid leukemia and the association of leukemia with glycemic control.
Patients & Methods: Patients with leukemia with and without diabetes (2007-2015) were retrospectively identified and matched 1:1 (n = 70 per group). Overall survival was estimated by the Kaplan-Meier method. Hemoglobin A 1c  and glucose levels the year after leukemia diagnosis were compared by mixed models.
Results: Among 25 of 70 patients with diabetes, mean hemoglobin A 1c during the year after leukemia diagnosis was 6.8%. Kaplan-Meier-estimated 3-year survival was 46% for diabetes patients versus 45% for controls (p = 0.79).
Conclusion: No associations were found between leukemia, diabetes, survival and glycemic control.
Competing Interests: Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.
(© 2020 Mayo Foundation for Medical Education and Research.)
Databáze: MEDLINE
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