Patterns of axono-cortical evoked potentials: an electrophysiological signature unique to each white matter functional site?

Autor: Boyer A; Brain Stimulation and Systems Neuroscience, INSERM, U1216, Grenoble, France., Stengel C; Frontlab, Institut du Cerveau, ICM, CNRS UMR 7225, INSERM, U1127, Paris, France., Bonnetblanc F; INRIA, LIRMM, CAMIN team, University of Montpellier, Montpellier, France., Dali M; Lariboisière Hospital, 2 rue Ambroise Paré, 75010, Paris, France., Duffau H; Gui de Chauliac Hospital, Montpellier, France.; Université de Montpellier, Montpellier, France., Rheault F; Sherbrooke Connectivity Imaging Lab, Department of Computer Science, Faculty of Sciences, Université de Sherbrooke, Sherbrooke, Canada., Descoteaux M; Sherbrooke Connectivity Imaging Lab, Department of Computer Science, Faculty of Sciences, Université de Sherbrooke, Sherbrooke, Canada., Guiraud D; INRIA, LIRMM, CAMIN team, University of Montpellier, Montpellier, France., Valero-Cabre A; Frontlab, Institut du Cerveau, ICM, CNRS UMR 7225, INSERM, U1127, Paris, France., Mandonnet E; Frontlab, Institut du Cerveau, ICM, CNRS UMR 7225, INSERM, U1127, Paris, France. mandonnet@mac.com.; Lariboisière Hospital, 2 rue Ambroise Paré, 75010, Paris, France. mandonnet@mac.com.; Université de Paris, Paris, France. mandonnet@mac.com.
Jazyk: angličtina
Zdroj: Acta neurochirurgica [Acta Neurochir (Wien)] 2021 Nov; Vol. 163 (11), pp. 3121-3130. Date of Electronic Publication: 2021 Jan 12.
DOI: 10.1007/s00701-020-04656-4
Abstrakt: Background: Brain-to-brain evoked potentials constitute a new methodology that could help to understand the network-level correlates of electrical stimulation applied for brain mapping during tumor resection. In this paper, we aimed to describe the characteristics of axono-cortical evoked potentials recorded from distinct, but in the same patient, behaviorally eloquent white matter sites.
Methods: We report the intraoperative white matter mapping and axono-cortical evoked potentials recordings observed in a patient operated on under awake condition of a diffuse low-grade glioma in the left middle frontal gyrus. Out of the eight behaviorally eloquent sites identified with 60-Hz electrical stimulation, five were probed with single electrical pulses (delivered at 1 Hz), while recording evoked potentials on two electrodes, covering the inferior frontal gyrus and the precentral gyrus, respectively. Postoperative diffusion-weighted MRI was used to reconstruct the tractograms passing through each of the five stimulated sites.
Results: Each stimulated site generated an ACEP on at least one of the recorded electrode contacts. The whole pattern-i.e., the specific contacts with ACEPs and their waveform-was distinct for each of the five stimulated sites.
Conclusions: We found that the patterns of ACEPs provided unique electrophysiological signatures for each of the five white matter functional sites. Our results could ultimately provide neurosurgeons with a new tool of intraoperative electrophysiologically based functional guidance.
(© 2021. Springer-Verlag GmbH Austria, part of Springer Nature.)
Databáze: MEDLINE
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