Risk indicators associated with in-hospital mortality and severity in patients with diabetes mellitus and confirmed or clinically suspected COVID-19.

Autor: Pazoki M; Department of Pulmonary Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Keykhaei M; Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran., Kafan S; Department of Pulmonary Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Montazeri M; Department of Infectious Diseases, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Mirabdolhagh Hazaveh M; Department of Endocrinology Medicine, Sina Hospital, Tehran University of Medical Sciences, Hasan Abad Sq, Tehran, Iran., Sotoodehnia M; Department of Emergency Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Kazemian S; Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran., Talebpour M; Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Ashraf H; Cardiac Primary Prevention Research Center (CPPRC), Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.; Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Shariat Moharari R; Department of Anesthesiology and Critical Care, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Majidi F; Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Hedayati Amlashi N; Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Zare S; Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Fathi M; Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Azimbeik Z; Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Ebrahimi M; Department of Endocrinology Medicine, Sina Hospital, Tehran University of Medical Sciences, Hasan Abad Sq, Tehran, Iran.
Jazyk: angličtina
Zdroj: Journal of diabetes and metabolic disorders [J Diabetes Metab Disord] 2021 Jan 07; Vol. 20 (1), pp. 59-69. Date of Electronic Publication: 2021 Jan 07 (Print Publication: 2021).
DOI: 10.1007/s40200-020-00701-2
Abstrakt: Purpose: This study aims to investigate risk indicators of in-hospital mortality and severity of coronavirus disease-2019 (COVID-19) in patients with diabetes mellitus (DM).
Methods: In this retrospective study, we studied patients with COVID-19 referred to Sina Hospital, Tehran, Iran, from February 20 to May 14, 2020. Patients with either a positive real-time reverse-transcriptase polymerase-chain-reaction test of swab specimens or high clinical suspicion according to the World Health Organization interim guidance were included. We accurately divided all patients into two groups based on diabetes affection and followed-up patients with DM based on incurring death, severe COVID-19, and in-hospital complications.
Results: We enrolled 574 patients with COVID-19 in the final analysis, of whom 176 (30.7%) patients had DM. In this study, 104 (18.1%) patients deceased, and 380 (66.2%) patients incurred severe COVID-19. We found that COVID-19 patients with DM had a significantly higher mortality rate ( P value<0.001), severe disease ( P value<0.001), and in-hospital complications (all P values<0.05). Besides that, in patients with DM, admission temperature (odds ratio (OR): 1.69, P value: 0.024), oxygen saturation (OR: 0.92, P value: 0.004), and urea (OR: 1.01, P value: 0.048) were independent risk indicators of in-hospital mortality. In addition, subgroup analysis of diabetic patients based on admission glucose level showed significant differences between these groups regarding acute cardiac injury ( P value: 0.044) and acute liver injury (P value: 0.002).
Conclusions: Patients with DM admitted with lower oxygen saturation, elevated temperature, and higher urea are more susceptible to progress to more severe COVID-19 and poor prognosis. This indicates a necessity for more precise care during hospitalization for these patients.
Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-020-00701-2.
Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest.
(© Springer Nature Switzerland AG 2021.)
Databáze: MEDLINE
Externí odkaz: