| Autor: |
Yoshimoto S; Next Generation Science Institute, Morinaga Milk Industry Co., Ltd ., Kanagawa, Japan., Mitsuyama E; Next Generation Science Institute, Morinaga Milk Industry Co., Ltd ., Kanagawa, Japan., Yoshida K; Next Generation Science Institute, Morinaga Milk Industry Co., Ltd ., Kanagawa, Japan., Odamaki T; Next Generation Science Institute, Morinaga Milk Industry Co., Ltd ., Kanagawa, Japan., Xiao JZ; Next Generation Science Institute, Morinaga Milk Industry Co., Ltd ., Kanagawa, Japan. |
| Jazyk: |
angličtina |
| Zdroj: |
Gut microbes [Gut Microbes] 2021 Jan-Dec; Vol. 13 (1), pp. 1-11. |
| DOI: |
10.1080/19490976.2020.1865705 |
| Abstrakt: |
We previously investigated the gut microbiota of 453 healthy Japanese subjects aged 0 to 104 years and found that the composition of the gut microbiota could be classified into some age-related clusters. In this study, we compared fecal metabolites between age-matched and age-mismatched elderly subjects to examine the roles of the gut microbiota in the health of the elderly. Fecal metabolites in 16 elderly subjects who fell into an age-matched cluster (elderly-type gut microbiota group, E-GM) and another 16 elderly subjects who fell into an age-mismatched cluster (adult-type gut microbiota group, A-GM) were measured by CE-TOF-MS. A total of eight metabolites were significantly different between the groups: cholic acid and taurocholic acid were enriched in the A-GM group, whereas choline, trimethylamine (TMA), N8-acetylspermidine, propionic acid, 2-hydroxy-4-methylvaleric acid, and 5-methylcytosine were enriched in the E-GM group. Some metabolites (choline, TMA, N8-acetylspermidine) elevated in the E-GM group were metabolites or precursors reported as risk factors for age-associated diseases such as arteriosclerosis and colorectal cancer. The abundance of some species belongs to Proteobacteria , which were known as TMA-producing bacteria, was increased in the E-GM group and correlated with fecal TMA levels. In vitro assays showed that these elderly-type fecal metabolites suppressed the expression of genes related to tight junctions in normal colonic epithelial cells and induced the expression of inflammatory cytokines in colon cancer cells. These findings suggest that metabolites produced by the aged gut microbiota could contribute to intestinal and systemic homeostasis and could be targeted for preventing aging-associated diseases. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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