A Prospective Study of Association of Micronutrients Deficiencies during Pregnancy and Neonatal Outcome among Women after Bariatric Surgery.

Autor: Ducarme G; Department of Obstetrics and Gynecology, Centre Hospitalier Departemental, 85000 La Roche sur Yon, France., Planche L; Clinical Research Center, Centre Hospitalier Departemental, 85000 La Roche sur Yon, France., Abet E; General Surgery Department, Bariatric Surgery Program, Centre Hospitalier Departemental, 85000 La Roche sur Yon, France., Desroys du Roure V; Clinical Research Center, Centre Hospitalier Departemental, 85000 La Roche sur Yon, France.; Department of Biology, Centre Hospitalier Departemental, 85000 La Roche sur Yon, France., Ducet-Boiffard A; Department of Endocrinology, Bariatric Surgery Program, Centre Hospitalier Departemental, 85000 La Roche sur Yon, France.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2021 Jan 08; Vol. 10 (2). Date of Electronic Publication: 2021 Jan 08.
DOI: 10.3390/jcm10020204
Abstrakt: Little is known about the association of micronutrients deficiencies during pregnancy and neonatal outcome among women after Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). We present a prospective study of 87 consecutive women with a history of RYGB ( n = 37) or SG ( n = 50) who underwent complete and regular clinical and biological nutritional assessments during pregnancy. Data on maternal characteristics, biological nutritional parameters, antenatal management, and perinatal outcome were collected. The objective was to evaluate serum levels of micronutrients at the second trimester, and to assess the association between micronutrients deficiencies and neonatal outcome. After RYGB, maternal age (34.3 ± 4.9 vs. 31.1 ± 4.6 years; p = 0.003) and pregnancy timing after surgery (64.5 ± 47.0 vs. 38.1 ± 28.1 months; p = 0.002) were significantly higher, and pre-pregnancy BMI was significantly lower (29.8 ± 5.6 vs. 32.9 ± 7.1 kg/m 2 ; p = 0.03). Maternal and neonatal outcomes were similar. Additional supplementations after blood tests were similar in groups. Zinc, selenium, vitamins A1, B1, B6, C, and E levels were not different depending on the type of surgery. Zinc deficiency (7/87) was significantly more frequent after RYGP (18.9% vs. 0%; p = 0.02) and selenium deficiency (15/87) was similar in groups (21.6% after RYGB and 14.0% after SG; p = 0.36). The mean birth weight was significantly lower in selenium deficiency cases (3137 ± 550 vs. 3535 ± 737 g; p = 0.04). Selenium deficiency was negatively correlated with birth weight ( r = -0.23; p = 0.03) and with birth weight z-score ( r = -0.26; p = 0.01), but not correlated after adjustment for the procedure. The levels of micronutrients surveillance along pregnancy in women with a history of bariatric surgery is necessary to decrease the risk of inadequate fetal growth in the patients.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje