| Autor: |
Dahir NS; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida.; Department of Internal Medicine, College of Medicine, University of Central Florida, Orlando, Florida., Calder AN; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida.; Department of Internal Medicine, College of Medicine, University of Central Florida, Orlando, Florida., McKinley BJ; Department of Biology, Utah State University, Logan, Utah., Liu Y; Department of Internal Medicine, College of Medicine, University of Central Florida, Orlando, Florida., Gilbertson TA; Department of Internal Medicine, College of Medicine, University of Central Florida, Orlando, Florida. |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2021 Mar 01; Vol. 320 (3), pp. E566-E580. Date of Electronic Publication: 2021 Jan 11. |
| DOI: |
10.1152/ajpendo.00331.2020 |
| Abstrakt: |
Sex as a biological variable has been the focus of increasing interest. Relatively few studies have focused, however, on differences in peripheral taste function between males and females. Nonetheless, there are reports of sex-dependent differences in chemosensitivity in the gustatory system. The involvement of endogenous changes in ovarian hormones has been suggested to account for taste discrepancies. Additionally, whether sex differences exist in taste receptor expression, activation, and subsequent signaling pathways that may contribute to different taste responsiveness is not well understood. In this study, we show the presence of both the nuclear and plasma membrane forms of estrogen receptor (ER) mRNA and protein in mouse taste cells. Furthermore, we provide evidence that estrogen increases taste cell activation during the application of fatty acids, the chemical cue for fat taste, in taste receptor cells. We found that genes important for the transduction pathway of fatty acids vary between males and females and that these differences also exist across the various taste papillae. In vivo support for the effect of estrogens in taste cells was provided by comparing the fatty acid responsiveness in male, intact female, and ovariectomized (OVX) female mice with and without hormone replacement. In general, females detected fatty acids at lower concentrations, and the presence of circulating estrogens increased this apparent fat taste sensitivity. Taken together, these data indicate that increased circulating estrogens in the taste system may play a significant role in physiology and chemosensory cellular activation and, in turn, may alter taste-driven behavior. NEW & NOTEWORTHY Using molecular, cellular, and behavioral analyses, this study shows that sex differences occur in fat taste in a mouse model. Female mice are more responsive to fatty acids, leading to an overall decrease in intake and fatty acid preference. These differences are linked to sex hormones, as estradiol enhances taste cell responsiveness to fatty acids during periods of low circulating estrogen following ovariectomy and in males. Estradiol is ineffective in altering fatty acid signaling during a high-estrogen period and in ovariectomized mice on hormone replacement. Thus, taste receptor cells are a direct target for actions of estrogen, and there are multiple receptors with differing patterns of expression in taste cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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