Different reference ranges affect the prevalence of osteoporosis and osteopenia in an urban adult Malaysian population.

Autor:	Yeap SS; Puchong Specialist Centre, Puchong, Selangor, Malaysia.; Department of Medicine, Subang Jaya Medical Centre, Subang Jaya, Selangor, Malaysia., Thambiah SC; Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Samsudin IN; Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Appannah G; Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Zainuddin N; Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Mohamad-Ismuddin S; Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Shahifar N; Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Md-Said S; Department of Community Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Zahari-Sham SY; Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Suppiah S; Department of Imaging, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Hew FL; Puchong Specialist Centre, Puchong, Selangor, Malaysia.; Department of Medicine, Subang Jaya Medical Centre, Subang Jaya, Selangor, Malaysia.
Jazyk:	angličtina
Zdroj:	Osteoporosis and sarcopenia [Osteoporos Sarcopenia] 2020 Dec; Vol. 6 (4), pp. 168-172. Date of Electronic Publication: 2020 Nov 27.
DOI:	10.1016/j.afos.2020.11.005
Abstrakt:	Objectives: To determine the prevalence of osteopenia (OPe) and osteoporosis (OP) in an urban adult population in Malaysia, and to compare the change in the prevalence when using a Caucasian compared to an Asian reference range. Methods: A cross-sectional random sample of the population aged between 45 and 90 years from the state of Selangor, Malaysia, was invited to attend a bone health check-up. Participants with diseases known to affect bone metabolism or who were on treatment for OP were excluded. Bone mineral density was measured using dual energy X-ray absorptiometry. Based on the World Health Organization definitions, the prevalence of OPe and OP was calculated using the Asian and Caucasian T-scores. Results: A total of 342 subjects (222 females, 120 males), with a mean age of 59.68 (standard deviation: 8.89) years, who fulfilled the study criteria were assessed. Based on the Asian reference range, there were 140 (40.9%) subjects with OPe and 48 (14.0%) with OP. On applying the Caucasian reference range, there were 152 (44.4%) subjects with OPe and 79 (23.1%) with OP, with significant increases in males, females, and Chinese ethnic groups. Overall, 75 (21.9%) of subjects had a change in their diagnostic status. T-scores were consistently lower when the Caucasian reference range was used. Conclusions: In a healthy urban Malaysian population, the prevalence of OP is 14.0% and OPe is 40.9%. Application of a Caucasian reference range significantly increased the number of subjects with OP and may potentially lead to over-treatment. Competing Interests: The authors declare no competing interests. (© 2020 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu