The Role of Complement in Myocardial Infarction Reperfusion Injury: An Underappreciated Therapeutic Target.
| Autor: | Vogel CW; University of Hawaii Cancer Center and Department of Pathology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in cell and developmental biology [Front Cell Dev Biol] 2020 Dec 23; Vol. 8, pp. 606407. Date of Electronic Publication: 2020 Dec 23 (Print Publication: 2020). |
| DOI: | 10.3389/fcell.2020.606407 |
| Abstrakt: | This article reviews the pathogenetic role of the complement system in myocardial infarction reperfusion injury. The complement activation pathways involved in myocardial tissue injury are identified, as are the complement-derived effector molecules. The results of past anti-complement therapies are reviewed; as the more recent therapeutic concept of complement depletion with humanized CVF described. Competing Interests: The author has a financial interest in iC3 LLC of Sunnyvale, CA, a company that develops therapeutics for complement depletion. (Copyright © 2020 Vogel.) |
| Databáze: | MEDLINE |
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