Selective and Improved Photoannealing of Microporous Annealed Particle (MAP) Scaffolds.

Autor:	Pfaff BN; Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22904, United States., Pruett LJ; Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22904, United States., Cornell NJ; Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22904, United States., de Rutte J; Department of Bioengineering, University of California-Los Angeles, Los Angeles, California 20095, United States., Di Carlo D; Department of Bioengineering, University of California-Los Angeles, Los Angeles, California 20095, United States., Highley CB; Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22904, United States.; Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904, United States., Griffin DR; Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22904, United States.; Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904, United States.
Jazyk:	angličtina
Zdroj:	ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2021 Feb 08; Vol. 7 (2), pp. 422-427. Date of Electronic Publication: 2021 Jan 06.
DOI:	10.1021/acsbiomaterials.0c01580
Abstrakt:	Microporous annealed particle (MAP) scaffolds consist of a slurry of hydrogel microspheres that undergo annealing to form a solid scaffold. MAP scaffolds have contained functional groups with dual abilities to participate in Michael-type addition (gelation) and radical polymerization (photoannealing). Functional groups with efficient Michael-type additions react with thiols and amines under physiological conditions, limiting usage for therapeutic delivery. We present a heterofunctional maleimide/methacrylamide 4-arm PEG macromer (MethMal) engineered for selective photopolymerization compatible with multiple polymer backbones. Rheology using two classes of photoinitiators demonstrates advantageous photopolymerization capabilities. Functional assays show benefits for therapeutic delivery and 3D printing without impacting cell viability.
Databáze:	MEDLINE
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