Baseline and overtime variations of soluble adhesion molecule plasma concentrations are associated with mobility recovery after rehabilitation in multiple sclerosis patients.

Autor: Ziliotto N; School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Lamberti N; Department of Biomedical and Surgical Specialties Sciences, University of Ferrara, Ferrara, Italy., Manfredini F; Department of Biomedical and Surgical Specialties Sciences, University of Ferrara, Ferrara, Italy; Department of Neurosciences/Rehabilitation, Unit of Physical and Rehabilitation Medicine, University Hospital of Ferrara, Ferrara, Italy., Straudi S; Department of Neurosciences/Rehabilitation, Unit of Physical and Rehabilitation Medicine, University Hospital of Ferrara, Ferrara, Italy., Tisato V; Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy., Carantoni M; Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy., Melloni E; Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy., Secchiero P; Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy., Basaglia N; Department of Neurosciences/Rehabilitation, Unit of Physical and Rehabilitation Medicine, University Hospital of Ferrara, Ferrara, Italy., Bernardi F; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy. Electronic address: ber@unife.it., Marchetti G; Department of Biomedical and Surgical Specialties Sciences, University of Ferrara, Ferrara, Italy.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2021 Mar 15; Vol. 352, pp. 577473. Date of Electronic Publication: 2021 Jan 02.
DOI: 10.1016/j.jneuroim.2020.577473
Abstrakt: Rehabilitative exercise outcomes and plasma concentrations of soluble adhesion molecules (sEndoglin, sE-Selectin, sL-Selectin, sICAM-1, sNCAM, sNCAM-1, sVCAM-1, sPECAM-1, sVAP-1) were evaluated in 60 severely disabled progressive multiple sclerosis (MS) patients at 4-time points. Changes of sE-Selectin, sL-Selectin, and sPECAM-1 concentrations were observed over time, and their variations were significantly correlated with rehabilitative outcome variations. Baseline sVAP-1 concentrations were able to predict functional mobility recovery. Our data suggest that the evaluation of adhesion molecules in plasma provides useful information to interpret rehabilitative exercise processes and to identify potential predictors of the rehabilitation-induced changes in mobility outcomes in MS patients.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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