Topological Twists in Nature.

Autor: Simien JM; Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI, USA., Haglund E; Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI, USA. Electronic address: ellinorh@hawaii.edu.
Jazyk: angličtina
Zdroj: Trends in biochemical sciences [Trends Biochem Sci] 2021 Jun; Vol. 46 (6), pp. 461-471. Date of Electronic Publication: 2021 Jan 05.
DOI: 10.1016/j.tibs.2020.12.004
Abstrakt: The first entangled protein was observed about 30 years ago, resulting in an increased interest for uncovering the biological functions and biophysical properties of these complex topologies. Recently, the Pierced Lasso Topology (PLT) was discovered in which a covalent bond forms an intramolecular loop, leaving one or both termini free to pierce the loop. This topology is related to knots and other entanglements. PLTs exist in many well-researched systems where the PLTs have previously been unnoticed. PLTs represents 18% of all disulfide containing proteins across all kingdoms of life. In this review, we investigate the biological implications of this specific topology in which the PLT-forming disulfide may act as a molecular switch for protein function and consequently human health.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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